Abcam, ab25919, Anti-Avian Influenza Matrix Protein I antibody

Size: 100µg
Rabbit Polyclonal M1 antibody. Suitable for WB and reacts with Recombinant full length protein - Influenza A samples. Cited in 2 publications.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Influenza A,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Protein G chromatography purified IgG., Storage buffer-pH: 7.4Preservative: 0.05% Sodium azideConstituents: PBS, 0.2% Gelatin, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Avian Influenza Matrix Protein I also known as M1 protein plays an important role in the viral life cycle by mediating assembly and budding of the virus. It has a molecular mass of approximately 27 kilodaltons. The M1 protein is expressed in the host cell's cytoplasm where it performs its functions. It binds directly to the inner surface of the viral lipid envelope and interacts with other viral components establishing its central role in maintaining the integrity and shape of the viral particle.
Biological function summary
M1 protein contributes to viral replication and organization within the infected host cell. It forms a complex with other viral proteins such as the envelope and nucleoprotein facilitating the packaging of viral RNA. By controlling the viral architecture M1 manages the export of ribonucleoprotein complexes out of the nucleus and participates in the antiviral resistance mechanisms of the virus. This protein through these interactions controls the infection efficiency and pathogenicity of the avian influenza virus.
Pathways
M1 protein integrates into several vital virological pathways including the viral assembly and replication pathways. It coordinates with other influenza proteins such as NP and NEP to transport the viral genome to the host cell membrane where new virions form and release. The RNA export pathway is another critical process where M1 protein plays an integral role ensuring that the viral RNA segments reach the sites for assembly and are incorporated into new virus particles.
The M1 protein is critical in understanding the pathogenicity and transmission of avian influenza. This protein influences the virulence of the influenza virus contributing to its capability to cause respiratory illness in birds and potentially mammals including humans. M1's interaction with other viral proteins like hemagglutinin (HA) is important for determining tissue tropism and host range factors that can lead to pandemics. Studying the M1 protein offers valuable insights into controlling and preventing outbreaks of influenza.