Abcam, ab261921, Recombinant human SGK2 protein (Active)

Size: 5µg / 10µg
Recombinant human SGK2 protein (Active) is a Human Full Length protein, in the 1 to 427 aa range, expressed in Baculovirus infected Sf9 cells, with >90%, suitable for SDS-PAGE, FuncS.
Key facts
Purity:>90% Densitometry,
Expression system:Baculovirus infected Sf9 cells,
Tags:GST tag N-Terminus,
Applications:FuncS, SDS-PAGESee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:Yes,
Biological activity:The specific activity of SGK2 was determined to by 74 nmol/min/mg.,
Accession:Q9HBY8,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 7.5Constituents: 25% Glycerol (glycerin, glycerine), 0.87% Sodium chloride, 0.79% Tris HCl, 0.00385% (R*,R*)-1,4-Dimercaptobutan-2,3-diol, 0.0038% EGTA, 0.00292% EDTA, 0.00174% PMSF

Properties and Storage Information:
Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SGK2 also known as serum/glucocorticoid regulated kinase 2 is a serine/threonine-protein kinase with a molecular mass of approximately 48 kDa. It plays mechanically important roles in cellular ion transport cell growth and survival. SGK2 is part of the larger AGC kinase family and shows a wide tissue distribution with notable expression in the liver pancreas kidney and heart. This kinase is activated in response to cellular stress or growth factors and functions in various cellular contexts.
Biological function summary
SGK2 contributes to cellular signaling processes that regulate sodium and potassium ion channels impacting cellular homeostasis. SGK2 does not function as part of a larger complex but still exerts significant influence on cell volume regulation and osmoregulation. It modulates activities of ion transporters and other kinases influencing fluid absorption in epithelial cells and metabolic processes highlighting its relevance in both normal physiology and pathophysiology.
Pathways
SGK2 integrates into signaling networks including the PI3K/AKT pathway and the mTOR pathway. Within these pathways SGK2 serves as a downstream target of PI3K activity participating in cellular responses to insulin and growth factors. The kinase interacts closely with proteins like AKT maintaining cell survival and metabolic balance. SGK2's role in these pathways points to its influence on anabolic processes and adaptive cell responses.
SGK2 has been linked to metabolic syndromes and hypertension. Its involvement in insulin signaling suggests a connection to type 2 diabetes where it interacts with proteins such as AKT2 to affect glucose metabolism and insulin sensitivity. SGK2's regulation of sodium balance also ties it to hypertension with implications for cardiovascular health. Its functional alterations in these contexts emphasize its potential as a therapeutic target in managing metabolic and cardiovascular disorders.