Abcam, ab26212, Anti-SSRP1 antibody [10D7]

Size: 100µg
Mouse Monoclonal SSRP1 antibody. Suitable for Flow Cyt, WB, ICC/IF and reacts with Human samples. Cited in 14 publications. Immunogen corresponding to Recombinant Fragment Protein within Human SSRP1.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:10D7,
Isotype:IgG2b,
Light chain type:kappa,
Carrier free:No,
Reacts with:Human,
Applications:WB, Flow Cyt, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human SSRP1. The exact immunogen used to generate this antibody is proprietary information.Q08945,
Specificity:ab26212 recognises Structure specific recognition protein 1 (SSRP1).

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification, Storage buffer-pH: 7.2Preservative: 0.09% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SSRP1 also known as Structure-Specific Recognition Protein 1 has an important role in DNA-related processes. This protein with a molecular weight of about 80 kDa binds DNA to regulate its structure during transcription and replication. SSRP1 localizes in the nucleus and expresses widely across various tissues indicating its broad functional significance. SSRP1 often pairs with SPT16 to form the FACT (Facilitates Chromatin Transcription) complex which aids in nucleosome disassembly and reassembly.
Biological function summary
SSRP1 is integral to processes involving chromatin reorganization and transcriptional regulation. It operates as a component of the FACT complex facilitating the modification of chromatin structure enabling access to the underlying DNA for active transcription. By altering nucleosome structure it assists RNA polymerase II in transcribing through chromatin directly influencing gene expression regulation.
Pathways
SSRP1 participates actively in DNA transcription and repair mechanisms. It is an essential player in the transcription elongation pathway interacting with RNA polymerase II. Additionally it influences the DNA repair pathways working in concert with proteins such as SPT16 and histones to maintain genomic stability. Its function ensures efficient transcription and protection against DNA damage.
SSRP1 connections emerge in the context of cancer and Alzheimer's disease. In cancer SSRP1 expression levels can correlate with tumor progression influencing the behavior of cancer cells through its role in transcriptional regulation. In Alzheimer's alterations in chromatin structure involving SSRP1 may link to disease progression. The activity of SSRP1 interacts with proteins such as p53 in cancer highlighting its role in disease mechanisms and potential as a therapeutic target.