Abcam, ab262868, Anti-GALNT2 antibody

Size: 100µL
Rabbit Polyclonal GALNT2 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human Polypeptide N-acetylgalactosaminyltransferase 2 aa 400 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human Polypeptide N-acetylgalactosaminyltransferase 2 aa 400 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q10471

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The GALNT2 protein also known as polypeptide N-acetylgalactosaminyltransferase 2 facilitates the initial step of mucin-type O-glycosylation by transferring N-acetylgalactosamine to serine or threonine residues on proteins. This enzyme has a molecular mass of approximately 69 kDa. GALNT2 expression occurs across various tissues with higher levels observed in the liver and small intestine. It plays a role in the modification of secreted and membrane-bound mucin glycoproteins.
Biological function summary
The function of GALNT2 extends beyond simple glycosylation. It contributes to protein sorting and stability within the Golgi apparatus. GALNT2 functions as a solitary entity and not within a larger protein complex. Its enzymatic activity has regulatory implications in lipid metabolism and signal transduction influencing the bioavailability of certain hormones and receptors by modifying glycans on their surface.
Pathways
GALNT2 plays roles in both the O-glycan biosynthesis pathway and the Wnt signaling pathway. In the O-glycan biosynthesis pathway GALNT2 interacts with other glycosyltransferases to ensure the proper glycosylation of proteins. Within the Wnt signaling pathway it indirectly influences the stability of certain proteins like frizzled receptors which are necessary for effective signaling. These pathways highlight GALNT2's integrative role in cellular processes such as development and homeostasis.
GALNT2 has an association with cardiovascular diseases and metabolic syndrome. Research shows that altered glycosylation patterns mediated by GALNT2 can affect the functionality of apolipoproteins like APOC3 thereby influencing lipid levels in the blood. Dysregulation of GALNT2 activity can lead to imbalances in these metabolic processes contributing to the pathogenesis of these conditions. Understanding GALNT2’s role presents potential therapeutic angles for managing such diseases.