Abcam, ab262889, Anti-SGPP1 antibody

Size: 100µL
Rabbit Polyclonal SGPP1 antibody. Suitable for ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human SGPP1 aa 250-300.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human SGPP1 aa 250-300. The exact immunogen used to generate this antibody is proprietary information.Q9BX95

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SGPP1 also known as sphingosine-1-phosphate phosphatase 1 is an enzyme that dephosphorylates sphingosine-1-phosphate (S1P) to sphingosine. This enzymatic activity helps regulate the levels of S1P a bioactive lipid involved in various cellular processes. The molecular mass of SGPP1 is approximately 50 kDa. SGPP1 is expressed in a variety of tissues including the liver brain and kidneys indicating its widespread role in the body.
Biological function summary
SGPP1 plays an important role in controlling the sphingolipid signaling pathway influencing cell growth survival and migration. It is not part of a larger complex but operates through interaction with S1P and its receptors. By removing phosphate groups from S1P SGPP1 reduces the signaling activity of this lipid mediator therefore influencing various biological responses including immune cell trafficking.
Pathways
SGPP1 functions within the sphingolipid metabolism pathway which is closely tied to the regulation of cellular processes such as proliferation and apoptosis. Its activity has a strong connection with S1P lyase which further degrades sphingosine. SGPP1 also interacts with enzymes involved in the ceramide synthesis pathway reflecting its role in balancing the levels of different sphingolipids that affect cellular functions.
SGPP1 affects conditions such as cancer and inflammation. Its ability to modulate S1P concentrations links it to tumor growth and spread as altered sphingolipid signaling can drive oncogenic processes. An additional association exists with inflammatory disorders where SGPP1 influences immune responses. SGPP1 interacts with SGPL1 another key enzyme in the sphingolipid pathway affecting these disease outcomes.