Abcam, ab262931, Anti-LIN52 antibody

Size: 100µL
Rabbit Polyclonal LIN52 antibody. Suitable for ICC/IF and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human LIN52 aa 1 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human LIN52 aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q52LA3

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
LIN52 also known as LINC01143 is a protein with a molecular mass of approximately 14 kDa. Mechanically LIN52 plays a role in regulating the cell cycle and transcription processes. It interacts with other proteins to form complexes that are important for controlling cellular processes. LIN52 is widely expressed in various tissues including the brain placenta and ovary indicating its significant contribution to multiple cell functions throughout the body.
Biological function summary
LIN52 is part of the DREAM complex which is involved in cell cycle regulation. This complex is essential for the repression of E2F-target genes during the quiescent phase of the cell cycle thereby inhibiting premature cell progression. LIN52's interaction with other elements of the DREAM complex allows for proper cell cycle arrest and its dysfunction can lead to uncontrolled cell proliferation.
Pathways
LIN52 is involved in the regulation of the cell cycle and transcription pathways. In the context of the cell cycle pathway it works alongside proteins like RB (Retinoblastoma) E2F and other members of the DREAM complex to maintain proper cell cycle control and response to proliferative signals. LIN52 also participates in transcription regulation pathways interacting with other transcriptional factors to modulate gene expression in response to cellular needs.
LIN52 dysfunction or altered expression is associated with several cancer types including ovarian and breast cancers. Its role in the DREAM complex links it to proteins such as RB whose mutations or inactivation are common in these cancers. LIN52's involvement in cell cycle control makes it a target of interest for understanding and potentially treating disorders characterized by abnormal cell growth.