Abcam, ab264170, Anti-BAF170 antibody

Size: 100µL
Rabbit Polyclonal BAF170 antibody. Suitable for IHC-P, IP, WB and reacts with Human, Mouse samples. Immunogen corresponding to Synthetic Peptide within Human SMARCC2 aa 1150 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:WB, IHC-P, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human SMARCC2 aa 1150 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q8TAQ2

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 6.8 - 7.4Preservative: 0.09% Sodium azideConstituents: Tris buffered saline, 0.1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
BAF170 also known as SMARCC2 is a protein that plays an essential role in chromatin remodeling. The molecular mass of BAF170 is approximately 131 kDa. It is expressed in various tissues including the brain and heart where it helps in altering chromatin structure to allow for transcriptional regulation. The protein contributes to the regulation of gene expression by modulating the accessibility of chromatin-bound transcription factors.
Biological function summary
BAF170 forms an integral part of the SWI/SNF chromatin remodeling complex which influences how genes are expressed in the cell. This complex alters the position of nucleosomes enabling the access of transcriptional machinery to DNA. Through this action BAF170 regulates the expression of genes necessary for processes such as cell differentiation and proliferation. The SWI/SNF complex interacts with multiple other proteins creating a dynamic regulatory environment for gene expression.
Pathways
BAF170 participates in significant cellular pathways like the Wnt signaling pathway and the Hedgehog pathway. These pathways influence many vital cellular processes including development and cell cycle regulation. In the Wnt pathway BAF170 works in concert with other proteins such as beta-catenin to regulate target gene expression. Similarly in the Hedgehog pathway BAF170 interacts with proteins involved in the signaling cascade affecting cellular responses and developmental processes.
Aberrations in BAF170 activity associate with certain cancers and neurodevelopmental disorders. Alterations in the SWI/SNF complex's function where BAF170 is a central component can result in malignant transformations leading to tumors. Moreover disruptions in BAF170's regulation are linked to issues impacting brain development possibly influencing conditions such as autism spectrum disorders. Researchers continue to investigate the protein's role in other pathological states providing insight into its contribution to disease mechanisms.