Abcam, ab264228, Anti-EIF3D antibody

Size: 100µL
Rabbit Polyclonal EIF3D antibody. Suitable for IP, WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human EIF3D aa 150-200.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human EIF3D aa 150-200. The exact immunogen used to generate this antibody is proprietary information.O15371

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 6.8 - 7.4Preservative: 0.09% Sodium azideConstituents: Tris buffered saline, 0.1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
EIF3D also known as eukaryotic translation initiation factor 3 subunit D is part of the EIF3 complex and plays a fundamental role in the initiation phase of protein synthesis. EIF3D has a molecular weight of approximately 66 kDa. It is expressed in various tissues with high levels observed in cells that have a high rate of protein synthesis such as those found in proliferating tissues.
Biological function summary
EIF3D integrates into the large EIF3 complex which consists of multiple subunits and is vital for the proper assembly of the 40S ribosomal subunit. This assembly process is essential for the initiation of translation acting as a scaffold for other initiation factors. EIF3D contributes to the stabilization and binding of mRNAs to the ribosome facilitating efficient translation initiation. The protein is integral for mRNA selection and because of its interaction within the complex it influences cellular proliferation and growth.
Pathways
EIF3D participates actively in translation initiation and mRNA surveillance pathways. These pathways regulate gene expression at the translational level maintaining the fidelity and quality control of protein synthesis. EIF3D works closely with EIF3E another subunit within the EIF3 complex to modulate these processes. Their interaction ensures the correct binding of mRNA and aids in the prevention of errors during protein synthesis.
EIF3D has been implicated in cancer due to its high expression in rapidly proliferating cells and its role in sustaining increased protein synthesis rates that tumors demand. Alterations in the expression or function of EIF3D may lead to aberrant pathways that support oncogenesis. Moreover EIF3D relates to viral infections where pathogens exploit the host's translational machinery for their replication. Proteins like EIF3A within the same complex often act in unison with EIF3D to facilitate viral protein production.