Abcam, ab264242, Anti-Optineurin antibody

Size: 100µg
Rabbit Polyclonal Optineurin antibody. Suitable for IP, WB and reacts with Human samples. Immunogen corresponding to Synthetic Peptide within Human OPTN aa 500 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human OPTN aa 500 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q96CV9

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: Tris citrate/phosphate, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Optineurin also known as OPTN is a multifunctional protein of approximately 67 kDa. It is expressed in various tissues including the retina where it plays a role in maintaining cellular functions. Optineurin interacts with several binding partners to execute its roles within the cell. It is involved in intracellular trafficking signaling and inflammation processes. As an essential component of the cellular machinery optineurin aids in proper cellular communication and responses.
Biological function summary
Optineurin influences different cellular processes notably autophagy and regulation of inflammation. It participates in forming a complex with other proteins to facilitate cargo transport and degradation via the autophagy-lysosome pathway. This function is important for removing damaged proteins and organelles ensuring cellular homeostasis. Inflammation regulation occurs through optineurin's ability to inhibit certain signaling pathways therefore modulating immune responses and preventing excessive inflammation.
Pathways
Optineurin plays a role in the NF-kB signaling pathway and the autophagic process. In NF-kB signaling it acts as a negative regulator by degrading specific signaling molecules. This regulation is necessary to prevent chronic inflammation and maintain immune balance. Within autophagy optineurin collaborates with other autophagy-related proteins like LC3 to facilitate the sequestration and clearance of cellular components preventing accumulation of damaged cellular materials.
Optineurin connects to conditions like glaucoma and amyotrophic lateral sclerosis (ALS). Mutations in the optineurin gene link to glaucoma as they can impair autophagy and lead to optic nerve damage. In the context of ALS optineurin mutations disrupt normal cellular functions contributing to motor neuron degeneration. The protein TDP-43 is often associated with ALS and interacts with optineurin in pathological processes affecting disease progression.