Abcam, ab264292, Anti-PHF23 antibody

Size: 100µg
Rabbit Polyclonal PHF23 antibody. Suitable for IHC-P, IP, WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human PHF23 aa 350 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IP, IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human PHF23 aa 350 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q9BUL5

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: Tris citrate/phosphate, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
PHF23 also known as Plant Homeodomain Finger 23 is a protein involved in chromatin dynamics and regulation of gene expression. It has a molecular mass of approximately 43 kDa. PHF23 contains a zinc finger domain which is important for its role in binding to histones. The protein expresses in various tissues but shows higher expression levels in certain organs like the brain and testes. Its expression pattern suggests an involvement in critical regulatory processes.
Biological function summary
PHF23 plays a role in the modification of chromatin structure influencing gene transcription. The protein participates in the formation of a complex that is involved in transcriptional repression. It particularly associates with components of the nucleosome acting as a mediator in processes that alter the accessibility of DNA for transcription factors and enzymes. The protein's ability to bind to chromatin allows it to directly impact the epigenetic state of cells.
Pathways
PHF23 is a part of the chromatin remodeling pathway and is involved in the regulation of gene transcription. Its interaction with methylated histones connects it to the pathway of histone modification. It works alongside other proteins like LSD1 which is a lysine-specific demethylase and this collaborative function influences the transcriptional output of the cell. The protein’s actions contribute to maintaining the balance between gene activation and repression which is essential for normal cellular functions.
PHF23 relates to conditions involving abnormal chromatin remodeling such as certain cancers. Its alteration affects the typical transcriptional control which can lead to tumorigenesis. The protein interacts with other proteins including members of the histone demethylase family like KDM1A influencing pathways that become dysregulated in cancerous states. Studies suggest that understanding PHF23's exact role offers potential therapeutic targets for diseases where chromatin misregulation plays an important role.