Abcam, ab264347, Anti-SHANK3 antibody

Size: 100µg
Rabbit Polyclonal SHANK3 antibody. Suitable for IP, WB and reacts with Human, Mouse samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human SHANK3 aa 1450-1550.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human SHANK3 aa 1450-1550. The exact immunogen used to generate this antibody is proprietary information.Q9BYB0

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: Tris citrate/phosphate, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle, Do Not Freeze

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The SHANK3 protein also known as ProSAP2 is a scaffold protein that plays an important role at the postsynaptic density of excitatory synapses. It has a mass of around 240 kDa. SHANK3 is expressed mainly in the brain but also present in heart spleen and kidneys. It interacts with various proteins through its multiple domains contributing to the structural integrity and signaling functions of synapses.
Biological function summary
SHANK3 connects the cytoskeleton to the membrane proteins maintaining synaptic structure and function. As a part of the postsynaptic density complex SHANK3 interacts with proteins like Homer and NMDA receptors to organize the signaling platforms. Its role in synaptic structure regulation influences neuronal connectivity which impacts brain function and development.
Pathways
SHANK3 interacts with the signaling cascade involved in synaptic plasticity and communication. Specifically it is important in the mTOR pathway which influences cell growth and synaptic protein synthesis and the glutamatergic synapse pathway essential for synaptic transmission. Within these pathways SHANK3 closely associates with proteins such as PSD-95 and SAPAP facilitating synaptic signal transduction.
SHANK3 mutations link to neurodevelopmental disorders including autism spectrum disorder (ASD) and Phelan-McDermid syndrome. These mutations can disrupt its interaction with proteins like PSD-95 affecting synaptic stability and leading to cognitive and social impairments. SHANK3's role in these conditions highlights the importance of proper synaptic signaling and structure for normal neurological function.