Abcam, ab264416, Anti-CD96 antibody [BLR065G] - BSA free

Size: 100µL
Rabbit Recombinant Monoclonal CD96 antibody. Suitable for ICC, IP, WB, IHC-P and reacts with Human samples. Cited in 5 publications. Immunogen corresponding to Recombinant Fragment Protein within Human CD96 aa 1-550.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:BLR065G,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC, IHC-P, IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human CD96 aa 1-550. The exact immunogen used to generate this antibody is proprietary information.P40200

Product details:
This product is sold under License from Bethyl Laboratories, Inc.

Properties and Storage Information:
Form-Liquid, Purification notes-Purified from cell culture supernatant., Storage buffer-pH: 7.8 - 8.6Preservative: 0.09% Sodium azideConstituents: 99% Borate buffered saline, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
CD96 also known as TACTILE is an immunoglobulin-like protein weighing approximately 65 kDa. This protein is expressed mostly on T cells and natural killer (NK) cells with its presence also noted on certain leukemic cells. CD96 functions mechanistically as an adhesion molecule mediating interaction between cells significantly involving in immune response modulation. Through binding proteins like CD155 it regulates immune cell migration and activity playing a significant role in cellular communication within the immune system.
Biological function summary
The CD96 protein contributes to the immune synapse formation by interacting with other cell surface and intracellular proteins. It is not directly part of a multiprotein complex but closely interacts with the receptor-ligand pairs within immune cell networks. It plays a role in the control of NK cell activity and helps maintain immune homeostasis by balancing activation and inhibition cues.
Pathways
The CD96 protein significantly impacts immunological pathways particularly those involving T cell and NK cell activation. It connects with pathways such as the DNAM-1 (CD226) and CD155 axis influencing immune cell recognition and response. These pathways regulate cellular activities like cytotoxicity and cytokine production where CD96 collaborates with proteins like DNAM-1 and TIGIT to fine-tune immune responses.
CD96 is closely associated with cancer and autoimmune diseases. Its expression level and functional role in cell adhesion and immune response modulation affect tumor immune evasion and surveillance often serving as a potential therapeutic target in cancer immunotherapy. Moreover its interactions with CD155 and DNAM-1 suggest its involvement in autoimmune conditions where regulation of immune cell activity becomes dysregulated pointing towards its relevance in diseases like rheumatoid arthritis.