Abcam, ab266474, Human TP53INP2 knockout HEK-293T cell line

Size: 2 x 1000000Cells / vial / 1000000Cells / vial
TP53INP2 KO cell line available to order. KO validated by. Free of charge wild type control available. Knockout achieved by using CRISPR/Cas9, Homozygous: 1 bp insertion in exon 4. To order both knockout and wild-type control cells: select 2 x 1000000Cells/vial. To order only knockout cells: select 1000000Cells/vial.
Key facts
Cell type:HEK-293T,
Species or organism:Human,
Tissue:Kidney,
Form:LiquidSee storage information,
Knockout validation:Sanger Sequencing,
Mutation description:Knockout achieved by using CRISPR/Cas9, Homozygous: 1 bp insertion in exon 4

Product details:
We will provide viable cells that proliferate on revival.
This product is subject to limited use licenses from The Broad Institute, ERS Genomics Limited and Sigma-Aldrich Co. LLC, and is developed with patented technology. For full details of the licenses and patents please refer to our
limited use license
patent pages

Properties and Storage Information:
Gene name-TP53INP2, Gene editing type-Knockout, Gene editing method-CRISPR technology, Knockout validation-Sanger Sequencing, Zygosity-Homozygous, Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--196°C, Appropriate long-term storage conditions--196°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TP53INP2 also known as p53-inducible nuclear protein 2 is a 104 amino acids protein with a molecular weight of approximately 12 kDa. This protein actively engages in the regulation of autophagy and transcription processes. It is mainly expressed in human tissues like the brain liver heart and pancreas. In cellular environments TP53INP2 moves between the nucleus and the cytoplasm which suggests it plays a dynamic role in cellular homeostasis by potentially interacting with different cellular structures.
Biological function summary
TP53INP2 plays a significant role in modulating the cellular stress response and apoptosis. It interacts with autophagy-related proteins to facilitate the degradation of damaged cellular components. TP53INP2 is not generally described as part of a larger protein complex but its interactions with several autophagy-related proteins underline its involvement in cellular cleaning and recycling systems aiding in the balance between cell survival and cell death.
Pathways
TP53INP2 connects to both the autophagy and apoptosis pathways. Within the autophagy pathway TP53INP2 collaborates with proteins like LC3 and Beclin-1 to promote the formation of autophagosomes. Meanwhile in apoptosis pathways TP53INP2 affects the activity of the tumor suppressor protein p53 providing a link between autophagic processes and programmed cell death especially under cellular stress conditions.
TP53INP2 correlates with cancer and neurodegenerative diseases. In cancer the interaction with p53 signifies a role in tumorigenesis where altered TP53INP2 expression might contribute to cancer progression. In neurodegenerative disorders such as Alzheimer's disease the role of TP53INP2 in autophagy becomes essential as impaired autophagy is often linked with such diseases. The protein's connections to key mechanisms suggest its potential as a therapeutic target in diseases where autophagy and cell death processes are disrupted.