Abcam, ab266559, Human KXD1 (C19orf50) knockout HEK-293T cell line

Size: 2 x 1000000Cells / vial / 1000000Cells / vial
KXD1 KO cell line available to order. KO validated by. Free of charge wild type control available. Knockout achieved by using CRISPR/Cas9, Homozygous: 1 bp insertion in exon 2. To order both knockout and wild-type control cells: select 2 x 1000000Cells/vial. To order only knockout cells: select 1000000Cells/vial.
Key facts
Cell type:HEK-293T,
Species or organism:Human,
Tissue:Kidney,
Form:LiquidSee storage information,
Knockout validation:Sanger Sequencing,
Mutation description:Knockout achieved by using CRISPR/Cas9, Homozygous: 1 bp insertion in exon 2

Product details:
We will provide viable cells that proliferate on revival.
This product is subject to limited use licenses from The Broad Institute, ERS Genomics Limited and Sigma-Aldrich Co. LLC, and is developed with patented technology. For full details of the licenses and patents please refer to our
limited use license
patent pages

Properties and Storage Information:
Gene name-KXD1, Gene editing type-Knockout, Gene editing method-CRISPR technology, Knockout validation-Sanger Sequencing, Zygosity-Homozygous, Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--196°C, Appropriate long-term storage conditions--196°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
C19orf50 also known as Chromosome 19 Open Reading Frame 50 is a protein that has a molecular weight of approximately 17 kDa. The protein expresses in various tissues throughout the body indicating a broad role within cellular activities. Though its exact mechanical function isn't fully determined it may interact with other proteins due to its expression levels across different systems.
Biological function summary
Proteins associated with C19orf50 engage in cellular development and maintenance. Evidence suggests it acts as part of a protein complex influencing key processes within cells. Its function may intersect with regulatory mechanisms affecting cellular growth and differentiation.
Pathways
Cellular processes involving C19orf50 are linked with cellular signal transduction and metabolic pathways. The protein potentially interacts with key players in these pathways such as mTOR signaling. This connection aids in modulating cellular energy balance with influences observed alongside proteins like AMPK which play a role in energy homeostasis and cellular response to stress.
C19orf50's role involves pathogeneses related to metabolic dysfunction and proliferative disorders. In the context of type 2 diabetes evidence suggests a possible interaction with insulin signaling proteins contributing to impaired glucose metabolism. Additionally research implicates its regulatory influence in some cancers possibly through modulation of pathways involving tumor suppressor proteins like p53.