Abcam, ab267359, Anti-KMT5C/SUV4-20h2 antibody

Size: 100µL
Rabbit Polyclonal KMT5C/SUV4-20h2 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human KMT5C aa 200-300.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human KMT5C aa 200-300. The exact immunogen used to generate this antibody is proprietary information.Q86Y97

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
KMT5C also known as SUV4-20h2 is a histone lysine methyltransferase. Mechanically it catalyzes the trimethylation of lysine 20 on histone H4 (H4K20me3) an important histone modification for DNA repair and regulation of chromatin structure. The molecular mass of KMT5C is approximately 48 kDa. KMT5C is expressed in various tissues with higher levels observed in the tissues involved in cell proliferation and differentiation like testes and bone marrow.
Biological function summary
KMT5C influences chromatin condensation and thereby contributes to genomic stability. The protein often functions as part of larger complexes involved in epigenetic regulation working closely with other chromatin-modifying proteins. By methylating H4K20 KMT5C plays a significant role in regulating cell cycle progression notably during the DNA damage response and repair processes. This function assists in maintaining proper cellular function and preventing aberrant cellular proliferation.
Pathways
KMT5C has significant involvement in the DNA damage repair pathway and the cell cycle regulation. Within these pathways it associates with proteins like 53BP1 an important player in DNA damage recognition and repair. KMT5C activity in histone modification integrates into the broader framework of chromatin remodeling necessary for efficient DNA repair and cell cycle control ensuring cellular maintenance in response to genomic insults.
Changes in KMT5C expression or function have associations with cancer and neurodevelopmental disorders. Aberrant methylation patterns caused by altered KMT5C activity can lead to genomic instability contributing to oncogenesis. Furthermore disturbances in its function may impact neural development potentially linking it to conditions such as autism spectrum disorder. KMT5C's relationship with proteins like E2F1 a regulator of cell cycle events highlights its relevance to these disease processes.