Abcam, ab269168, Recombinant human FGF4 protein (Active)

Size: 5µg / 25µg / 100µg
Recombinant human FGF4 protein (Active) is a Human Full Length protein, in the 31 to 206 aa range, expressed in Escherichia coli, with >95%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE, FuncS.
Key facts
Purity:>95% SDS-PAGE,
Endotoxin level:< 1 EU/µg,
Expression system:Escherichia coli,
Tags:Tag free,
Applications:FuncS, SDS-PAGESee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:Yes,
Biological activity:NR6R-3T3 Proliferation ED50 ≤ 5 ng/mL (≥2.0 x 10^5 units/mg).,
Accession:P08620,
Animal free:No,
Carrier free:Yes,
Species:Human,
Reconstitution:Reconstitute at 0.1 mg/mL in water,
Storage buffer:Constituents: 0.29% Sodium chloride, 0.16% Sodium phosphate

Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Working aliquots stored with a carrier protein are stable for at least 3 months at -20°C to -80°C.

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The FGF4 protein also known as fibroblast growth factor 4 is an important player in cell proliferation differentiation and survival. It is part of the fibroblast growth factor family which consists of over 20 known members. The FGF4 protein has a mass of approximately 22 kDa. Researchers observe its expression in various tissues including the embryo and certain adult tissues where it contributes to developmental processes and tissue repair. FGF4 signalling plays a significant role in embryogenesis.
Biological function summary
FGF4 protein regulates pathways involved in cell development and morphogenesis. It particularly influences the formation of limbs and the development of the nervous system. FGF4 usually functions as a part of signaling complexes interacting with its specific receptors on the cell surface. These interactions will lead to a cascade of downstream signaling events that modulate gene expression and cellular behavior.
Pathways
FGF4 engages with multiple signaling pathways notably the MAPK/ERK pathway and the PI3K/AKT pathway. Through these pathways FGF4 protein orchestrates cellular responses important for proper tissue organization and differentiation. It often functions alongside other proteins like FGF2 and FGF8 which share overlapping roles in similar developmental and cellular processes. These interactions underline the complexity and redundancy within the fibroblast growth factor family in ensuring robust biological outcomes.
Dysregulation of FGF4 protein associates with conditions like cancer and developmental defects. Overactive FGF4 signaling has been linked to tumor growth and progression as it can drive unchecked cellular proliferation and survival. Furthermore altered FGF4 expression may relate to syndromes affecting limb development. In the context of these diseases FGF4 can interact with proteins such as FGFR1 leading to aberrant signaling pathways contributing to pathogenesis.