Abcam, ab270980, Anti-ATF-4 antibody [EPR24346-182]

Size: 10µL-TRIAL / 20µL / 100µL / 1mL
Anti-ATF-4 antibody [EPR24346-182] is a Rabbit Monoclonal antibody that is used in ATF-4 Western Blot. Suitable for Human samples. ATF-4 (CREB-2) is a transcription factor which binds the tax-responseive enhancer element in the LTR of HTLV-1. Expression of ATF-4 is induced in response to cell stres and can function as either a transctiptional activator or a repressor.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR24346-182,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Activating Transcription Factor 4 (ATF-4) also known as CREB-2 is a fundamental protein involved in cellular stress responses. It functions mechanically as a transcription factor that regulates gene expression in reaction to stress signals. The molecular weight of ATF-4 is approximately 38 kDa. ATF-4 gets expressed in various tissues including the brain liver and pancreas reflecting its involvement in diverse cellular processes. Scientists widely use techniques like Western blot to detect and study ATF-4 expression patterns due to its reliable measurement of the ATF-4 molecular weight.
Biological function summary
ATF-4 participates in controlling genes linked to amino acid metabolism redox homeostasis and apoptosis. It does not work alone; ATF-4 often forms part of larger complexes interacting with other transcription factors like C/EBP and ATF-3 to exert its effects. These interactions enable it to respond accurately to different types of cellular stress by adjusting the expression of specific genes ensuring that cells can adapt to changing conditions.
Pathways
ATF-4 plays a significant role in the integrated stress response (ISR) and the unfolded protein response (UPR). Through these pathways it collaborates with proteins such as PERK (protein kinase R-like endoplasmic reticulum kinase) and eIF2α. The ISR and UPR help cells cope with stress by modulating protein synthesis and promoting the expression of protective genes. By interacting with these pathways ATF-4 contributes to maintaining cellular homeostasis and protecting cells from damage.
ATF-4 has been linked to conditions such as neurodegenerative diseases and cancer. In neurodegenerative disorders like Alzheimer's disease ATF-4 can regulate genes involved in neuronal survival and apoptosis interacting with proteins like CHOP. In cancer ATF-4 influences tumor cell survival and growth through its role in stress responses. Understanding ATF-4's relationship with diseases highlights its potential as a therapeutic target in the treatment of these complex disorders.