Abcam, ab272350, Alexa Fluor® 700 Anti-CD94 antibody [KLRD1]

Size: 100Test
Mouse Monoclonal CD94 antibody - conjugated to Alexa Fluor® 700. Suitable for Flow Cyt and reacts with Human samples. Immunogen corresponding to Cell preparation containing KLRD1 protein.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:KLRD1,
Isotype:IgG1,
Light chain type:kappa,
Conjugation:Alexa Fluor® 700,
Excitation/Emission:Ex: 702nm, Em: 723nm,
Carrier free:No,
Reacts with:Human,
Applications:Flow CytSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Cell preparation containing KLRD1 protein. The exact immunogen used to generate this antibody is proprietary information.Q13241

Product details:
Alexa Fluor® is a registered trademark of Molecular Probes, Inc, a Thermo Fisher Scientific Company. The Alexa Fluor® dye included in this product is provided under an intellectual property license from Life Technologies Corporation. As this product contains the Alexa Fluor® dye, the purchase of this product conveys to the buyer the non-transferable right to use the purchased product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). As this product contains the Alexa Fluor® dye the sale of this product is expressly conditioned on the buyer not using the product or its components, or any materials made using the product or its components, in any activity to generate revenue, which may include, but is not limited to use of the product or its components: in manufacturing; (ii) to provide a service, information, or data in return for payment (iii) for therapeutic, diagnostic or prophylactic purposes; or (iv) for resale, regardless of whether they are sold for use in research. For information on purchasing a license to this product for purposes other than research, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com.

Properties and Storage Information:
Form-Liquid, Purification technique-Size-exclusion chromatography, Purification notes-Purified from TCS., Storage buffer-pH: 7.4Preservative: 0.1% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
CD94 also known as killer cell lectin-like receptor subfamily D member 1 (KLRD1) plays a significant mechanical role in the immune system. This protein forms part of a receptor family involved in natural killer (NK) cell function. CD94 typically assembles on the cell surface as a heterodimer often pairing with NKG2 proteins. Weighing approximately 30 kDa CD94 mainly exhibits expression on NK cells and a subset of T cells where it contributes to immune regulation.
Biological function summary
CD94 is essential in recognizing and binding to non-classical MHC class I molecules when it pairs with NKG2 molecules such as NKG2A or NKG2C. This dimer forms a complex receptor which plays an important role in modulating NK cell activity. Through this receptor complex CD94 influences the immune response by either inhibiting or activating NK cells depending on its NKG2 partner. This regulation helps maintain a balanced immune response preventing excessive activation and autoimmunity.
Pathways
CD94 interacts with the signaling pathways related to the immune response. In particular it is involved in the natural killer cell lectin-like receptor signaling pathway. This pathway manages the activation and inhibition of NK cells integrating signals received through various receptors including CD94/NKG2 dimers. Associated proteins like DAP12 may amplify these signals which ultimately influence cytotoxic activities and cytokine production.
CD94 has notable connections with conditions such as cancer and viral infections. For example certain tumors manipulate CD94 expression on NK cells to evade immune surveillance. Additionally alterations in CD94 and its partner molecules like NKG2A have been observed in viral infections possibly affecting how the immune system responds. Understanding CD94's relationship with these diseases can offer insights into potential therapeutic strategies targeting immune regulation.