Abcam, ab272390, Anti-GPCR GPR64 antibody [EPR23658-2]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal GPCR GPR64 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Human, Mouse, Rat samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR23658-2,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:IHC-P, WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The GPCR GPR64 also known as ADGRG2 is a member of the adhesion G protein-coupled receptor family. It is characterized by large extracellular domains facilitating cell adhesion and signaling. This receptor has a mass of approximately 98 kDa. GPR64 is mainly expressed in the epididymis and plays an important role in reproductive tissues. Moreover it displays a basal activity that implicates several signaling pathways.
Biological function summary
GPCR GPR64 functions as a mediator of reproductive tract development. It is not currently known to be part of any larger complex. However its signaling contributes to the modulation of fluid reabsorption in the epididymis affecting sperm maturation and storage. Beyond the reproductive system some studies suggest roles in other tissues like osteoblasts and kidney cells.
Pathways
Several pieces of research have tied GPCR GPR64 to the cAMP signaling pathway influencing the regulation of epithelial sodium channels. This impacts ion transport and homeostasis within the reproductive tissues. Additionally other proteins such as epithelial sodium channel (ENaC) have shown interactions with GPR64 affecting fluid dynamics. Further research is exploring potential connections to the Wnt signaling pathway due to similar functional roles.
GPCR GPR64 has been linked to disorders affecting fertility such as reduced sperm motility leading to male infertility. Also abnormal expression patterns have been observed in some cancer types like prostate cancer. The interaction with ENaC makes it particularly interesting in understanding how dysregulation might impact these conditions on a cellular level providing insights for potential therapeutic targets.