Abcam, ab272597, Anti-TRIM66 antibody

Size: 100µL
Rabbit Polyclonal TRIM66 antibody. Suitable for ICC/IF and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human TRIM66 aa 850-1000.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human TRIM66 aa 850-1000. The exact immunogen used to generate this antibody is proprietary information.O15016

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TRIM66 also known as RING finger protein 207 is a member of the tripartite motif (TRIM) family of proteins. This protein has a molecular mass of approximately 138 kDa and is expressed in various tissues including the testis and embryonic stem cells. Mechanically TRIM66 contains RING B-box and coiled-coil (RBCC) domains which facilitate protein-protein interactions and contribute to ubiquitin E3 ligase activities. These domains allow TRIM66 to modulate protein stability by attaching ubiquitin to substrate proteins marking them for degradation or functional modulation.
Biological function summary
The activity of TRIM66 plays an important role in gene regulation and chromatin remodeling. TRIM66 acts as a cofactor that modulates transcription factors and chromatin structures impacting the transcription of specific genes. It associates with chromatin remodeling complexes and contributes to gene silencing or activation by influencing histone modifications. Through these mechanisms TRIM66 is involved in processes such as cell differentiation and development.
Pathways
TRIM66 is involved in key cellular pathways particularly those regulating gene expression and cell differentiation. It interacts with histone tail modifications that are critical in the chromatin modification pathway influencing gene activation states. TRIM66 also has connections with the TGF-beta signaling pathway interacting with other proteins like Smad2/3 to modulate their activity in transcription regulation. These interactions place TRIM66 as an influential player in cellular signaling networks.
TRIM66 has associations with cancer and developmental disorders. Abnormal expression or mutations of TRIM66 can lead to dysregulated cell growth contributing to tumorigenesis. The protein's interactions with cancer-related pathways link it to conditions like testicular cancer. Additionally TRIM66's role in chromatin remodeling and gene expression implicate it in developmental disorders that arise from aberrant gene regulation. It interacts with proteins such as p53 an important regulator in tumor suppression connecting TRIM66 to both cancer progression and potential therapeutic strategies.