Abcam, ab272613, Anti-GSTM3 antibody

Size: 100µL
Rabbit Polyclonal GSTM3 antibody. Suitable for IHC-P, WB and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human GSTM3 aa 150 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human GSTM3 aa 150 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.P21266

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
GSTM3 also known as Glutathione S-transferase Mu 3 is a protein that plays a role in detoxification processes. This enzyme belongs to the GST superfamily which assists in conjugating glutathione to hydrophobic and electrophilic compounds. GSTM3 has a molecular weight of approximately 26 kDa. It is expressed in various tissues including the brain liver and testis indicating its involvement in diverse physiological functions.
Biological function summary
GSTM3 facilitates the neutralization of reactive oxygen species protecting cells from oxidative damage. This protein interacts with intracellular substrates engaging in phase II metabolic reactions. While GSTM3 does not form larger multimeric complexes it partners with glutathione to stabilize and detoxify harmful compounds. This role highlights GSTM3’s importance within cellular defense mechanisms.
Pathways
GSTM3 participates in the xenobiotic metabolism and the glutathione pathway. These pathways involve the biotransformation of toxic substances where GSTM3 works in tandem with related proteins like CYP450 enzymes. GSTM3's activity in the glutathione pathway interconnects with the regulation of oxidative stress highlighting its part in cellular resilience against environmental challenges.
GSTM3 has connections to neurological disorders and certain cancers. Its involvement in detoxification processes links it to the neurodegenerative condition Parkinson's disease where oxidative stress plays a critical role. In certain cancers variations in GSTM3 expression levels influence tumor development and aggressiveness. GSTM3's interaction with proteins involved in these conditions such as GSTP1 offers potential insights into therapeutic strategies.