Abcam, ab272661, Anti-HNRPDL antibody

Size: 100µL
Rabbit Polyclonal HNRPDL antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human HNRNPDL aa 100-150.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human HNRNPDL aa 100-150. The exact immunogen used to generate this antibody is proprietary information.O14979

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
HNRPDL also known as heterogeneous nuclear ribonucleoprotein D-like is a protein with a mass of about 42 kDa. It plays an important role in RNA processing activities like splicing transportation stabilization and degradation. The protein is part of the hnRNP family which contains versatile nucleic acid-binding proteins involved in various aspects of mRNA processing and metabolism. HNRPDL is expressed in multiple tissues including high levels in muscle heart and brain indicating its broad functional importance.
Biological function summary
HnRNP D-like protein participates in regulating gene expression post-transcriptionally. It often forms a complex with other hnRNP proteins enabling the modulation of RNA metabolic processes. This protein binds to RNA through its nucleic acid-binding domains influencing the mRNA stability and pre-mRNA processing. It affects various cellular processes by regulating gene transcripts vital for maintaining normal cellular functions.
Pathways
HnRNP D-like protein is part of key processes that influence mRNA splicing and transport. It is involved in the mRNA surveillance pathway that monitors and degrades abnormal mRNA molecules. HNRPDL also interacts with other proteins like HNRNPA1 in these pathways showing its importance in RNA regulation and cellular homeostasis. Its function in these pathways suggests it plays a role in ensuring the accuracy of mRNA synthesis and processing.
Altered HNRPDL function is linked to conditions such as myopathy and some neurodegenerative diseases. Mutations or dysregulation in hnRNP D-like protein can affect muscle tissues and might contribute to muscle degeneration disorders. Additionally its abnormal function may also relate to neurological disorders potentially through pathways that involve other hnRNP family members like HNRNPA1. Understanding its connection to these diseases could provide insights into potential therapeutic targets for related conditions.