Abcam, ab272675, Anti-HES4 antibody

Size: 100µL
Rabbit Polyclonal HES4 antibody. Suitable for ICC/IF and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human HES4 aa 1-50.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human HES4 aa 1-50. The exact immunogen used to generate this antibody is proprietary information.Q9HCC6

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
HES4 also known as Hairy and Enhancer of Split 4 is a transcription factor with a molecular mass of roughly 26 kDa. It belongs to the basic helix-loop-helix (bHLH) family and is known for its role in modulating transcriptional repression. HES4 is expressed in various tissues including neural tissues where it contributes to the regulation of cellular differentiation and development. Its expression is significant during embryonic development indicating its role in early cellular identity.
Biological function summary
The function of HES4 involves transcriptional regulation of genes important for developmental processes. It often acts as a part of a transcriptional repression complex modulating gene expression patterns necessary for cellular differentiation. HES4 plays a vital role in the Notch signaling pathway influencing the balance between proliferation and differentiation of neural progenitor cells. By functioning within this complex HES4 ensures specific transcriptional outcomes are achieved impacting cell fate decisions.
Pathways
The involvement of HES4 in the Notch signaling pathway is significant. This pathway is pivotal for controlling cell fate and lineage commitment in various cell types particularly during nervous system development. Moreover HES4's interaction with other bHLH proteins such as HES1 further integrates its role into these pathways fine-tuning the outcome of cell differentiation processes. This interaction highlights the importance of HES4 in maintaining proper cellular function and development.
Aberrations in HES4 activity have been linked to developmental disorders specifically within the nervous system such as neural tube defects. Its misregulation can impact cell differentiation processes leading to improper tissue development. Additionally alterations in HES4 have associations with certain cancers particularly those involving abnormal cell proliferation. In these contexts HES4's relationship with the Notch pathway along with factors like HES1 highlights its relevance in disease progression and potential therapeutic targets.