Abcam, ab273391, Linsitinib (OSI-906)

Size: 10mg / 50mg
MW 421.5 Da, Purity 98%. Potent and selective dual IGF-1R (IC 50 = 35 nM in cell-free assay) and Insulin Receptor (IC 50 = 75 nM in cell-free assay) kinase inhibitor. Inactive towards Abl, ALK, BTK, EGFR, FGFR1/2 and PKA. Displayed <50% inhibition at 1 μM against a panel of 88 kinases. Blocks IGF-1R autophosphorylation and downstream activation of Akt, ERK1/2 and S6 kinase. Blocks tumor cell line proliferation. Blocks IGF-1R driven tumor xenograft growth.
Key facts
CAS number:867160-71-2,
Purity:98%,
Form:SolidSee storage information,
Molecular weight:421.5 Da,
Molecular formula:C26H23N5O,
PubChem:11640390,
Nature:Synthetic,
Solubility:Soluble in DMSO to 50 mM,
Biochemical name:Linsitinib,
Biological description:Potent and selective dual IGF-1R (IC50 = 35 nM in cell-free assay) and Insulin Receptor (IC50 = 75 nM in cell-free assay) kinase inhibitor. Inactive towards Abl, ALK, BTK, EGFR, FGFR1/2 and PKA. Displayed <50% inhibition at 1 μM against a panel of 88 kinases. Blocks IGF-1R autophosphorylation and downstream activation of Akt, ERK1/2 and S6 kinase. Blocks tumor cell line proliferation. Blocks IGF-1R driven tumor xenograft growth.,
Canonical smiles:CC1(CC(C1)C2=NC(=C3N2C=CN=C3N)C4=CC5=C(C=C4)C=CC(=N5)C6=CC=CC=C6)O,
InChi:InChI=1S/C26H23N5O/c1-26(32)14-19(15-26)25-30-22(23-24(27)28-11-12-31(23)25)18-8-7-17-9-10-20(29-21(17)13-18)16-5-3-2-4-6-16/h2-13,19,32H,14-15H2,1H3,(H2,27,28),
InChiKey:PKCDDUHJAFVJJB-UHFFFAOYSA-N,
IUPAC Name:3-[8-amino-1-(2-phenylquinolin-7-yl)imidazo[1,5-a]pyrazin-3-yl]-1-methylcyclobutan-1-ol

Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-Store under desiccating conditions