Abcam, ab2740, Anti-Hepatitis C Virus Core 1b antibody [C7-50]

Size: 100µg
Mouse Monoclonal POLG antibody. Suitable for IP, Flow Cyt, ELISA, WB and reacts with Hepatitis C virus samples. Cited in 99 publications.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:C7-50,
Isotype:IgG1,
Carrier free:No,
Reacts with:Hepatitis C virus,
Applications:ELISA, IP, WB, Flow CytSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Epitope:This antibody recognizes an epitope between amino acid residues 21-40 of HCV core protein. This sequence is conserved among different HCV strains.,
Specificity:Detects hepatitis C virus (HCV) core protein from transfected human and primate cell lines.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-Preservative: 0.05% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The Hepatitis C Virus Core 1b also recognized as HCV Core Protein or sometimes abbreviated as HCV Core is an important structural protein of the Hepatitis C Virus weighing approximately 21 kDa. This protein is mainly expressed in infected liver cells playing a central role in the virus's life cycle. It forms part of the viral nucleocapsid providing a protective shell for the viral genome. Through its structural role HCV Core Protein ensures the stability and integrity of the viral particles necessary for efficient infection and replication.
Biological function summary
The Hepatitis C Virus Core Protein influences various cellular processes. It interacts with host cell signaling pathways and cellular structures to facilitate viral replication. As part of a larger proteins complex the core protein contributes to the production of virus particles. Moreover it possesses regulatory roles that impact gene transcription and modulation of host cell immune responses further aiding viral propagation and persistence within the host.
Pathways
Studies show that HCV Core Protein is involved in disrupting normal cellular pathways such as the PI3K-Akt pathway which is significant for cell survival and anti-apoptosis mechanisms. It interacts with proteins like p53 and Bcl-2 which further link to the JAK-STAT pathway involved in immune modulation. These interactions illustrate how the core protein manipulates host cell environments to benefit viral survival and replication while potentially triggering pathogenic pathways within the host.
The Hepatitis C Virus Core Protein holds connections to liver diseases notably chronic hepatitis and hepatocellular carcinoma. These conditions arise from the persistent infection and the core protein's interference with apoptotic and immune pathways contributing to carcinogenesis. It relates closely with other viral proteins like NS5A which together exacerbate liver fibrosis and cancer development. The core protein's pathogenic role highlights its interest as a target for anti-HCV therapies potentially guiding therapeutic antibody development against hepatitis C like anti-HCV core antibodies or anti-hepatitis C antibodies.