Abcam, ab275632, Anti-Marapsin1 antibody [107]

Size: 100µL
Rabbit Recombinant Monoclonal Marapsin1 antibody. Suitable for IP, WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human PRSS27.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:107,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human PRSS27.Q9BQR3

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Marapsin1 also known as PRSS27 is a serine protease with a molecular mass of approximately 25 kDa. It functions by cleaving peptide bonds in substrates which is typical for enzymes belonging to its class. Expression of Marapsin1 occurs mainly in epithelial tissues especially in the skin and some glandular tissues like the pancreas. Its role is linked to various cellular mechanisms dependent on proteolytic processes.
Biological function summary
This protease contributes to essential cellular processes such as keratinization and epidermal differentiation. It is not part of any large multiprotein complexes but interacts closely with substrates involved in skin barrier formation. The specificity of Marapsin1’s substrate recognition plays a significant role in maintaining the integrity and proper function of epithelial tissues.
Pathways
Marapsin1 is involved in the epidermal differentiation pathway which is important for skin health and regeneration. This pathway includes other proteins such as filaggrin and loricrin which are important for skin barrier formation. Marapsin1's precise proteolytic actions help modulate the availability and activity of these proteins thereby ensuring proper skin structure and resilience against external stress.
Disrupted Marapsin1 activity is associated with skin conditions particularly psoriasis and atopic dermatitis. These conditions often involve altered epidermal differentiation processes. Marapsin1's interaction with proteins like filaggrin suggests its significance in maintaining healthy skin. Abnormalities in these interactions can lead to compromised skin integrity triggering or exacerbating these disorders.