Abcam, ab27591, Anti-DDX4 / MVH antibody [mAbcam27591]

Size: 100µg
Anti-DDX4 / MVH antibody [mAbcam27591] (ab27591) is a mouse monoclonal antibody detecting DDX4 / MVH in Western Blot, IHC-P, IHC-Fr, ICC/IF . Suitable for Common marmoset, Human, Mouse . - Over 100 publications
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:mAbcam27591,
Isotype:IgG1,
Light chain type:kappa,
Carrier free:No,
Reacts with:Mouse, Human, Common marmoset,
Applications:ICC/IF, IHC-P, WB, IHC-FrSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
What is this antibody validated in?
Anti-DDX4 / MVH antibody [mAbcam27591] (ab27591) is a mouse monoclonal antibody and is validated for use in Western Blot (WB), Immunohistochemistry (IHC-P), Immunohistochemistry (IHC-Fr), Immunocytochemistry/immunofluorescence (ICC/IF) in Common marmoset, Human, Mouse samples.
What is the molecular weight of DDX4 / MVH?
Anti-DDX4 / MVH [mAbcam27591] (ab27591) specifically detects a band for DDX4 / MVH (UniProt: Q9NQI0) at a molecular weight of 76kDa.
Trusted by the scientific community
Anti-DDX4 / MVH [mAbcam27591] (ab27591) was first used in a scientific publication in 2012 and has been cited over 100 times in peer-reviewed journals.
Reviewed by scientists
Anti-DDX4 / MVH [mAbcam27591] (ab27591) has over 5 independent reviews from customers.
Other related products
We have a range of other formats of antibody clone [mAbcam27591] also available for your convenience: ab27591, Carrier free -
ab180462
, HRP -
ab196709
Want a custom formulation?
This antibody clone is manufactured by Abcam. If you require a custom buffer formulation or conjugation for your experiments, please contact orders@abcam.com

Properties and Storage Information:
Form-Liquid, Purity-IgG fraction, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 6.97% L-Arginine, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
DDX4 also known as MVH is a protein that functions as an ATP-dependent RNA helicase. This protein with a molecular mass of approximately 79 kDa belongs to the DEAD box protein family. DDX4 localizes mostly in germ cells and is notably present in the testis of organisms like chickens. Its expression is significant in the cytoplasm of spermatocytes and oocytes where it plays an essential role in the regulation of RNA metabolism during germ cell development.
Biological function summary
DDX4 supports RNA processes including splicing transport and stability within germ cells. The protein contributes to the assembly of protein-RNA complexes essential for cellular function. It operates in germ cell development by ensuring proper RNA handling and regulation. DDX4 also contributes to the formation of germ granules cellular structures important for RNA processing and storage in germ cells.
Pathways
DDX4 is involved in germ cell development and differentiation. It plays a role in pathways regulating meiosis and gametogenesis cooperating with proteins like PIWIL1. Within these pathways DDX4 influences small RNA pathways which are important for gene regulation during germ cell maturation. This action underlines the protein's relevance in reproductive biology and cellular lifecycle management within the gonads.
Alterations in DDX4 expression or function have associations with infertility and germ cell tumors. Aberrant activities of DDX4 can disrupt normal germ cell development linking it to disorders affecting fertility. The protein shares connections with TDRD9 another protein associated with germ cell development implicating them in similar reproductive health issues. Understanding DDX4's function could lead to better insights into reproductive diseases and potential therapeutic targets.