Abcam, ab276055, Anti-SULT2B1 antibody [007] - BSA and Azide free

Size: 100µL
Rabbit Recombinant Monoclonal SULT2B1 antibody. Carrier free. Suitable for IP, WB and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human SULT2B1 aa 1 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:007,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Human,
Applications:WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human SULT2B1 aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.O00204

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SULT2B1 also known as sulfotransferase family 2B member 1 functions as a cytosolic enzyme that adds sulfate groups to various molecules. This post-translational modification is important for the metabolism of hormones neurotransmitters drugs and xenobiotic compounds. SULT2B1 has a molecular mass of approximately 42 kDa. It is expressed in a variety of tissues with higher levels in the skin brain and reproductive organs indicating its diverse physiological roles across different systems in the body.
Biological function summary
The role of SULT2B1 involves the sulfation of cholesterol and dehydroepiandrosterone (DHEA) which are important for maintaining lipid homeostasis and steroid hormone biosynthesis. The enzyme is not part of a complex but works optimally in its standalone cytosolic environment. It participates actively in regulating the availability of active hormones and lipids making it a significant player in cellular metabolic processes.
Pathways
SULT2B1 operates within two main biological frameworks: the steroid hormone biosynthesis pathway and lipid metabolic pathway. In these pathways the enzyme interacts closely with cholesterol and DHEA to modulate their sulfation status influencing precursor availability for steroidogenesis. It works in conjunction with other sulfotransferases like SULT1A1 that also help manage the sulfate pool important for hormone regulation and metabolic balance.
Aberrations in SULT2B1 function can link to conditions like polycystic ovary syndrome (PCOS) and certain cancers due to its role in steroid hormone metabolism. Disruptions in the enzyme's activity could alter DHEA and cholesterol sulfation leading to hormone imbalances that contribute to these disorders. In the context of PCOS associated enzymes might include subtypes of cytochrome P450 which function alongside SULT2B1 in steroid biosynthesis pathways to maintain hormone equilibrium.