Abcam, ab277103, Anti-TRIM27 antibody [PCRP-TRIM27-1B3]

Size: 100µg
Mouse Monoclonal TRIM27 antibody. Suitable for ICC, Flow Cyt, Protein Array and reacts with Human, Recombinant full length protein - Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human TRIM27.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:PCRP-TRIM27-1B3,
Isotype:IgG2a,
Carrier free:No,
Reacts with:Human,
Applications:Flow Cyt, ICC, Protein ArraySee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human TRIM27.P14373

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A/G, Purification notes-Purified from bioreactor concentrate, Storage buffer-Preservative: 0.05% Sodium azideConstituents: PBS, 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TRIM27 also known as RFP is a protein that belongs to the tripartite motif (TRIM) family. It has a molecular mass of approximately 55 kDa. This protein contains a RING finger one or two B-box motifs and a coiled-coil region which assists in its function as an E3 ubiquitin ligase. It is involved in the ubiquitination process by facilitating the transfer of ubiquitin from the E2 ubiquitin-conjugating enzyme to substrate proteins. TRIM27 is expressed in various tissues with notable expression in the kidney lung and testis.
Biological function summary
This protein is involved in regulating several cellular processes including apoptosis cell cycle progression and transcription. It forms part of certain multiprotein complexes which enables it to interact with a diverse array of substrates. By influencing transcription factors TRIM27 can modulate gene expression patterns and cellular responses to environmental signals. Moreover it plays a role in maintaining cellular homeostasis through its involvement in protein degradation machinery.
Pathways
TRIM27 participates in the ubiquitin-proteasome system and is associated with the regulation of NF-κB signaling. It interacts with proteins such as TRAF2 and NEMO impacting pathways involved in cell survival and inflammatory responses. Both of these pathways are critical for cellular adaptation to stress emphasizing the role of TRIM27 in protecting cells from external and internal challenges.
TRIM27 has been implicated in cancer and autoimmune conditions. It has connections to breast cancer where its dysregulation may promote oncogenic pathways by altering protein stability. The protein also interacts with components like NOD2 in autoimmune disease pathways suggesting a link to inflammatory bowel disease. These associations indicate that TRIM27 could serve as a potential target for therapeutic intervention.