Abcam, ab277777, Anti-GSK3 (alpha + beta) (phospho Y216 + Y279) antibody [19HCLC]

Size: 100µg
Rabbit Recombinant Multiclonal GSK3 alpha phospho Y216 + Y279 antibody. Suitable for ICC, WB and reacts with Human, Mouse samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human Glycogen synthase kinase-3 alpha phospho Y216 + Y279 aa 200-250.
Key facts
Host species:Rabbit,
Clonality:Multiclonal,
Clone number:19HCLC,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:ICC, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human Glycogen synthase kinase-3 alpha phospho Y216 + Y279 aa 200-250. The exact immunogen used to generate this antibody is proprietary information.P49840

Product details:
What are recombinant multiclonals?
Recombinant multiclonals are a mixture of recombinant antibodies co-expressed from a library of heavy and light chains. They offer several advantages including:
- The sensitivity of polyclonal antibodies by recognising multiple epitopes
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
View our range of
recombinant multiclonal antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Preservative: 0.09% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The GSK3 protein known also as glycogen synthase kinase 3 has two isoforms: GSK3 alpha and GSK3 beta. Both isoforms have distinct yet significant mechanical roles. GSK3 alpha with a molecular weight of approximately 51 kDa and GSK3 beta weighing about 47 kDa act as serine/threonine kinases. These proteins are expressed in various tissues including the brain pancreas and liver. GSK3 is involved in the regulation of numerous cellular processes by phosphorylating its substrates impacting various cellular activities.
Biological function summary
GSK3 is integral in multiple signaling pathways and participates in the regulation of inflammation cell cycle and apoptosis. As part of the larger complex of signaling proteins GSK3 impacts the modulation of transcription factors and influences cellular differentiation and proliferation. The protein's kinase activity is necessary for maintaining cellular homeostasis and ensuring proper response to external signals.
Pathways
GSK3 influences critical pathways like Wnt and PI3K/Akt. Within the Wnt pathway GSK3 targets important proteins such as β-catenin where it plays an important role in controlling gene expression related to cell growth. In the PI3K/Akt pathway GSK3 acts as an important regulatory protein affecting insulin signaling and energy metabolism. Interactions with other kinases and transcription factors allow GSK3 to integrate various signaling cues that dictate cellular responses.
GSK3 has associations with neurodegenerative diseases and diabetes. In Alzheimer's disease GSK3 is linked to the formation of tau protein tangles contributing to neuronal dysfunction. Moreover in the context of diabetes GSK3 is involved in the insulin signaling pathway where dysregulation can lead to insulin resistance. It interacts with proteins such as tau in neurodegeneration and insulin receptor substrates in diabetes showing its significant role in these pathological conditions.