Abcam, ab278503, Anti-beta Catenin non-phospho S37/T41 antibody [EPR23969-131] - BSA and Azide free

Size: 100µg / 1mg
Rabbit Recombinant Monoclonal beta Catenin antibody. Carrier free. Suitable for IHC-P, ICC/IF, IP, Dot, WB and reacts with Rat, Mouse, Human, Synthetic peptide - Human samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR23969-131,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Mouse, Rat, Human,
Applications:Dot, WB, ICC/IF, IP, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
ab278503 is the carrier-free version of
ab246504
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Compatibility
This product is compatible with the Maxpar
Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar
is a trademark of Fluidigm Canada Inc.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Beta-catenin non-phospho S37/T41 also known as unphosphorylated beta-catenin is an important form of the beta-catenin protein. The mass of beta-catenin is approximately 88 kDa. This protein plays an active role in cell signaling and adhesion mechanics. It is expressed throughout various tissues particularly abundant in epithelial cells. The non-phospho form of beta-catenin in particular escapes degradation allowing it to accumulate and translocate into the nucleus where it influences gene transcription.
Biological function summary
Beta-catenin non-phospho S37/T41 affects cellular behavior by modulating gene expression. It acts as a core component of the Wnt signaling pathway particularly in the regulation of gene transcription. In this pathway beta-catenin associates with transcription factors such as TCF/LEF to regulate target gene expression involved in processes like cell proliferation and differentiation. Unphosphorylated beta-catenin binds with protein complexes that regulate adhesion to ensure proper communication between cells.
Pathways
Beta-catenin non-phospho S37/T41 plays a pivotal role in the Wnt pathway a critical regulator of cell fate decisions. Within this context beta-catenin's stabilization and nuclear activity are vital for the pathway's transcriptional output. It works closely with proteins like APC (adenomatous polyposis coli) and Axin which act as regulators of its phosphorylation. Additionally beta-catenin interacts with E-cadherin at the cell membrane within the adherens junctions contributing to cell-cell adhesion processes.
Beta-catenin non-phospho S37/T41 has significant implications in oncology and degenerative diseases. Its dysregulation is often observed in cancers where the aberrant accumulation leads to unchecked cell proliferation. Mutations or alterations in the related protein APC can lead to colorectal cancer as it fails to regulate beta-catenin effectively. Further alterations in the Wnt/beta-catenin pathway have also been linked to degenerative conditions indicating the broad impact of this target in pathological states.