Abcam, ab278783, PE Anti-Lyn (phospho Y507) antibody [LynY507-5B6]

Size: 10Test / 100Test
Rabbit Recombinant Monoclonal LYN phospho Y507 antibody - conjugated to PE. Suitable for Flow Cyt and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human LYN phospho Y507.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:LynY507-5B6,
Isotype:IgG,
Light chain type:kappa,
Conjugation:PE,
Excitation/Emission:Ex: 480;565nm, Em: 578nm,
Carrier free:No,
Reacts with:Human,
Applications:Flow CytSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human LYN phospho Y507. The exact immunogen used to generate this antibody is proprietary information.P07948

Product details:
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A/G, Storage buffer-Preservative: 0.09% Sodium azideConstituents: PBS, 0.2% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Store in the dark

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Lyn kinase also known as p56 or Lyn protein is a member of the Src family of protein tyrosine kinases. It possesses a molecular weight of approximately 56 kDa. Lyn is mainly expressed in hematopoietic cells such as B-lymphocytes mast cells and myeloid cells. It plays a critical role in the signaling pathways involving these cells. Lyn is located on the inner surface of the plasma membrane and requires lipid modification for membrane association. Additionally it is present in neuronal tissues and other non-immune cell types reflecting a broader role in cellular signal transduction.
Biological function summary
As a regulator in signal transduction Lyn kinase is involved in the formation of protein complexes that modulate cell activation and proliferation. It participates in the phosphorylation of downstream substrates which leads to the initiation of various cellular responses. Lyn modulates pathways involving inflammation and immune responses impacting the development and function of immune cells. It is important for balancing activation and inhibition signals in the immune system ensuring a controlled immune response.
Pathways
Lyn kinase interacts with the B-cell receptor (BCR) signaling pathway and the Fc epsilon RI signaling pathway in mast cells. It associates with other Src family kinases like Fyn and Lck to regulate BCR signaling which influences B-cell development and differentiation. Lyn also acts upstream of pathways that control the release of inflammatory mediators. Through its role in these pathways Lyn indirectly impacts downstream processes and affects cellular communication and immune system homeostasis.
Lyn dysfunction has implications for conditions like chronic myeloid leukemia and systemic lupus erythematosus. Abnormal Lyn activity alters signal transduction leading to unregulated cell proliferation and immune dysregulation. In chronic myeloid leukemia Lyn interacts with the BCR/ABL fusion protein contributing to the malignant transformation of hematopoietic cells. In systemic lupus erythematosus Lyn regulates signaling pathways that prevent autoimmunity; imbalances can lead to an excessive immune response. These connections highlight Lyn's importance in both cell regulation and its involvement in pathological states.