Abcam, ab279389, Anti-FKLF / KLF11 antibody [OTI4H7]

Size: 50µL
Mouse Monoclonal FKLF / KLF11 antibody. Suitable for WB and reacts with Recombinant fragment - Human, Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human KLF11 aa 1-300.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:OTI4H7,
Isotype:IgG1,
Carrier free:No,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human KLF11 aa 1-300. The exact immunogen used to generate this antibody is proprietary information.O14901

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A/G, Purification notes-Purified from TCS., Storage buffer-pH: 7.3Preservative: 0.02% Sodium azideConstituents: 50% Glycerol (glycerin, glycerine), 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
FKLF also known as KLF11 is a transcription factor of the Krüppel-like family vital for regulating gene expression. This protein has a mass of approximately 55 kDa and is expressed widely in various human tissues including the pancreas liver and heart. KLF11 has functional domains that bind to specific DNA sequences influencing the transcription process. The protein can act as an activator or repressor impacting cellular responses depending on the context of DNA.
Biological function summary
The transcription factor KLF11 plays significant roles in cellular differentiation and proliferation. It serves as part of a regulatory complex involved in modulating gene expression associated with cell cycle control and apoptosis. KLF11 exerts its effects by binding to specific promoter regions in target genes facilitating transcriptional activation or repression to modulate cellular states. The protein's activity is important for maintaining normal cell function and tissue homeostasis.
Pathways
KLF11 is integrated into important signaling networks such as the TGF-beta and SMAD pathways. In these pathways KLF11 interacts with various proteins including SMAD3 and SMAD4 to regulate downstream transcriptional responses. By influencing these pathways KLF11 participates in controlling processes like cell growth inhibition and apoptosis ensuring regulated cell proliferation and differentiation. These interactions highlight KLF11's role in orchestrating multiple cellular functions and maintaining physiological balance.
Mutations or dysregulation of KLF11 expression have been implicated in diabetes mellitus and certain cancers. In diabetes KLF11’s modulation of insulin gene expression links it to metabolic regulation where it affects glucose homeostasis. In some cases of cancer aberrant KLF11 activity contributes to uncontrolled cell proliferation suggesting a tumor suppressor role. KLF11 associates with target proteins like SMAD3 during these disease processes highlighting its involvement in their pathogenesis.