Abcam, ab281096, Anti-beta Amyloid 1-38 antibody [EPR1878(2)] - BSA and Azide free (Detector)

Size: 100µg / 1mg
Rabbit Recombinant Monoclonal Amyloid-beta precursor protein antibody. Carrier free. Suitable for sELISA and reacts with Mouse, Rat, Human samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR1878(2),
Isotype:IgG,
Carrier free:Yes,
Reacts with:Mouse, Rat, Human,
Applications:sELISASee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
ab281096 is a BSA and Azide Free antibody supplied in an unconjugated format and it is suitable for sandwich ELISAs to quantify Human Amyloid-beta 38 protein. The recommended pair for sandwich ELISA is:
Capture:
ab281246
, Human Amyloid-beta 38 protein Capture Antibody (unconjugated)
Detector: ab281096, Human Amyloid-beta 38 protein Detector Antibody (unconjugated)
The reference range value is 7.81-500 pg/mL.
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Sandwich ELISA
The recommended antibody orientation is based on internal optimization for ELISA-based assays. Antibody orientation is assay dependent and needs to be optimized for each assay type. Please note that the range provided for this antibody is only an estimation based on the performance of the product using the recommended antibody pair. Performance of the antibody pair will depend on the specific characteristics of your assay. We guarantee the product works in sandwich ELISA, but we do not guarantee the sensitivity or dynamic range of the antibody in your assay.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Beta Amyloid 1-38 also known as Aβ1-38 is a peptide that originates from the amyloid precursor protein (APP) through proteolytic processing. This peptide has a mass of approximately 4.17 kDa. Aβ1-38 is expressed in the brain and other tissues and it plays a role in the complex network of amyloidogenic processing. Its generation results from the sequential cleavage of APP by beta-secretase and gamma-secretase enzymes where it is one of the shorter forms of amyloid-beta peptides produced.
Biological function summary
Beta amyloid 1-38 participates in amyloid plaque formation which is significant in neurodegenerative processes. This peptide is part of a heterogenous group of amyloid-beta peptides which includes other forms like beta amyloid 1-40 and beta amyloid 1-42. Aβ1-38 contributes to the complex accumulation and aggregation of amyloid fibrils that have implications in synaptic functions and neuronal health. Its interactions influence cell signaling pathways and processes involved in cellular stress responses.
Pathways
Beta amyloid 1-38 plays a role in the amyloidogenesis pathway. This pathway impacts the regulation of synaptic activity and neural communication. The peptide is integrated into pathways connected with mitochondrial function and oxidative stress influencing how neurons react to metabolic demands. Proteins related to this pathway include presenilin which is a component of the gamma-secretase complex responsible for APP processing and tau protein which is involved in microtubule stability within cells.
Beta amyloid 1-38 is important in the pathology of Alzheimer's disease. The peptide's accumulation contributes to the formation of amyloid plaques a hallmark of the disease. Another disorder linked to beta amyloid peptide aggregates is cerebral amyloid angiopathy where the deposition in cerebral vessels can lead to vascular damage. Aβ1-38's relationship with proteins such as tau which forms neurofibrillary tangles in Alzheimer's highlights shared pathogenic mechanisms in these disorders.