Abcam, ab281910, Anti-Tim 2 antibody [RMT2-14] - Rabbit IgG (Chimeric)

Size: 200µg
Rabbit Recombinant Monoclonal Tim 2 antibody. Suitable for ICC/IF and reacts with Mouse samples. Cited in 1 publication. Immunogen corresponding to Recombinant Protein within Mouse Timd2 aa 1-250.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:RMT2-14,
Isotype:IgG,
Light chain type:lambda,
Carrier free:No,
Reacts with:Mouse,
Applications:ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Protein within Mouse Timd2 aa 1-250. The exact immunogen used to generate this antibody is proprietary information.Q8R183

Product details:
ab281910 is the chimeric rabbit version of
ab281909
This rabbit monoclonal chimeric antibody was made using the variable domain sequences of the original Rat IgG2a format, for improved compatibility with existing reagents, assays and techniques.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-Preservative: 0.02% Proclin 300Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
T-cell immunoglobulin and mucin domain 2 (Tim-2) also known as HAVCR2 is a protein with a molecular mass of approximately 80 kDa. Tim-2 expresses mainly in the immune system particularly in T cells B cells and dendritic cells. It acts as a receptor with a potential role in regulating the immune response. Tim-2 also presents in various tissues including the liver and kidney suggesting its involvement in multiple physiological processes.
Biological function summary
Tim-2 plays an important role in immune regulation and functions as a part of the broader family of T-cell immunoglobulin and mucin domain proteins. It does not typically form part of a complex but interacts with phosphatidylserine a phospholipid exposed during cell apoptosis. This interaction suggests Tim-2 has roles in recognizing apoptotic cells and may influence their removal by macrophages. Additionally it affects lymphocyte activity possibly by modulating T-cell proliferation and cytokine release.
Pathways
Tim-2 influences immune responses and cell survival pathways. It connects to the phosphatidylserine-mediated clearance pathway a critical component of maintaining tissue homeostasis and preventing inflammation by promoting the clearance of dying cells. Tim-2 also interacts with related proteins such as Tim-3 which shares similar ligand-binding properties and roles in immune response modulation.
Tim-2 relates to its role in immune system regulation and its connection to inflammatory disorders and autoimmune diseases. It is implicated in conditions like multiple sclerosis and asthma. In multiple sclerosis Tim-2 and Tim-3 can influence the immune tolerance and inflammation rate affecting disease progression. These connections highlight Tim-2 as a potential target for therapeutic interventions in autoimmune and inflammatory diseases.