Abcam, ab282420, THZ1

Size: 5mg / 25mg
MW 566.1 Da, Purity 97%. A potent (IC 50 = 15.6nM at 20 minutes) and selective inhibitor that combines allosteric covalent binding and ATP-site binding to irreversibly inhibit cyclin-dependent kinase 7 (CDK7). It demonstrates strong anti-proliferative effects across types of cancers and cell lines by disrupting transcription of several proteins and decreasing binding of STAT3 chromatin and target gene expression of genes such as MYC and PIM1.
Key facts
CAS number:1604810-83-4,
Purity:97%,
Form:SolidSee storage information,
Molecular weight:566.1 Da,
Molecular formula:C31H28ClN7O2,
PubChem:73602827,
Nature:Synthetic,
Solubility:Soluble in DMSO (up to at least 25 mg/ml),
Biochemical name:Thz1,
Biological description:A potent (IC50 = 15.6nM at 20 minutes) and selective inhibitor that combines allosteric covalent binding and ATP-site binding to irreversibly inhibit cyclin-dependent kinase 7 (CDK7). It demonstrates strong anti-proliferative effects across types of cancers and cell lines by disrupting transcription of several proteins and decreasing binding of STAT3 chromatin and target gene expression of genes such as MYC and PIM1.,
Canonical smiles:CN(C)CC=CC(=O)NC1=CC=C(C=C1)C(=O)NC2=CC=CC(=C2)NC3=NC=C(C(=N3)C4=CNC5=CC=CC=C54)Cl,
Isomeric smiles:CN(C)C/C=C/C(=O)NC1=CC=C(C=C1)C(=O)NC2=CC=CC(=C2)NC3=NC=C(C(=N3)C4=CNC5=CC=CC=C54)Cl,
InChi:InChI=1S/C31H28ClN7O2/c1-39(2)16-6-11-28(40)35-21-14-12-20(13-15-21)30(41)36-22-7-5-8-23(17-22)37-31-34-19-26(32)29(38-31)25-18-33-27-10-4-3-9-24(25)27/h3-15,17-19,33H,16H2,1-2H3,(H,35,40)(H,36,41)(H,34,37,38)/b11-6+,
InChiKey:OBJNFLYHUXWUPF-IZZDOVSWSA-N,
IUPAC Name:N-[3-[[5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl]amino]phenyl]-4-[[(E)-4-(dimethylamino)but-2-enoyl]amino]benzamide

Product details:
Solutions in DMSO may be stored at -20°C for up to 3 months.

Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-Store under desiccating conditions