Abcam, ab282421, PRL-3 Inhibitor I

Size: 5mg / 25mg
MW 485.2 Da, Purity 98%. A potent inhibitor of PRL-3, IC 50 =0.9 μM. Sensitizes PRL-3-expressing cancer cells to chemotherapeutics. Inhibits dephosphorylation of tyrosine-783 of integrin β1 in BGC823 and SW480 cells. Reduces the invasive properties of mouse melanoma B16F10 cells in a cellular model.
Key facts
Purity:98%,
Form:SolidSee storage information,
Molecular weight:485.2 Da,
Molecular formula:C17H11Br2NO2S2,
PubChem:73707371,
Nature:Synthetic,
Solubility:Soluble in DMSO (up to 40 mg/ml),
Biochemical name:5-[[5-Bromo-2-[(2-bromophenyl)methoxy]phenyl]methylene]-2-thioxo-4-thiazolidinone,
Biological description:A potent inhibitor of PRL-3, IC50=0.9 μM. Sensitizes PRL-3-expressing cancer cells to chemotherapeutics. Inhibits dephosphorylation of tyrosine-783 of integrin β1 in BGC823 and SW480 cells. Reduces the invasive properties of mouse melanoma B16F10 cells in a cellular model.,
Canonical smiles:C1=CC=C(C(=C1)COC2=C(C=C(C=C2)Br)C=C3C(=O)NC(=S)S3)Br,
Isomeric smiles:C1=CC=C(C(=C1)COC2=C(C=C(C=C2)Br)/C=C/3\C(=O)NC(=S)S3)Br,
InChi:InChI=1S/C17H11Br2NO2S2/c18-12-5-6-14(22-9-10-3-1-2-4-13(10)19)11(7-12)8-15-16(21)20-17(23)24-15/h1-8H,9H2,(H,20,21,23)/b15-8+,
InChiKey:HXNBAOLVPAWYLT-OVCLIPMQSA-N,
IUPAC Name:(5E)-5-[[5-bromo-2-[(2-bromophenyl)methoxy]phenyl]methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one

Product details:
Solutions in DMSO may be stored at -20°C for up to 2 months.

Properties and Storage Information:
Shipped at conditions-Ambient - Cannot Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-Store under desiccating conditions