Abcam, ab282423, WH-4-023

Size: 5mg / 25mg
MW 568.7 Da, Purity >98%. Potent and selective inihbitor of the tyrosine kinases Lck and Src with IC 50 values of 2 nM for Lck and 6 nM for Src.
Key facts
CAS number:837422-57-8,
Purity:>98%,
Form:PowderSee storage information,
Molecular weight:568.7 Da,
Molecular formula:C32H36N6O4,
PubChem:11844351,
Nature:Synthetic,
Solubility:Soluble in DMSO: 20 mg/ml.,
Biochemical name:2,6-Dimethylphenyl (2,4-dimethoxyphenyl)(2-((4-(4-methylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)carbamate,
Biological description:Potent and selective inihbitor of the tyrosine kinases Lck and Src with IC50 values of 2 nM for Lck and 6 nM for Src.,
Canonical smiles:CC1=C(C(=CC=C1)C)OC(=O)N(C2=C(C=C(C=C2)OC)OC)C3=NC(=NC=C3)NC4=CC=C(C=C4)N5CCN(CC5)C,
InChi:InChI=1S/C32H36N6O4/c1-22-7-6-8-23(2)30(22)42-32(39)38(27-14-13-26(40-4)21-28(27)41-5)29-15-16-33-31(35-29)34-24-9-11-25(12-10-24)37-19-17-36(3)18-20-37/h6-16,21H,17-20H2,1-5H3,(H,33,34,35),
InChiKey:NBTNHSGBRGTFJS-UHFFFAOYSA-N,
IUPAC Name:(2,6-dimethylphenyl) N-(2,4-dimethoxyphenyl)-N-[2-[4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]carbamate

Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The targets p38 Src VEGF Receptor 2 and Lck play significant roles in various cellular processes. p38 also known as MAPK14 is part of the mitogen-activated protein kinase (MAPK) family and it has a mass of about 41 kDa. It is widely expressed in many tissues like the heart skeletal muscle and liver. Src a non-receptor tyrosine kinase weighs approximately 60 kDa and resides in the cytoplasm and membranes of cells. VEGF Receptor 2 also known as KDR or FLK-1 is integral to cell signaling and shows a molecular weight of 150 kDa. It is found in endothelial cells facilitating vascular growth. Lck a lymphocyte-specific tyrosine kinase with a mass of roughly 56 kDa localizes mainly in T-cells and is important for T-cell receptor signaling.
Biological function summary
These proteins perform essential functions in cellular signaling. p38 for instance regulates inflammatory responses by activating downstream effectors in stress-stimulated pathways. Src plays a significant role in the regulation of cell division and survival by interacting with various signal transducers. VEGF Receptor 2 is fundamental to angiogenesis a process vital for new blood vessel formation. It participates in a complex with VEGF to transmit signals for endothelial cell proliferation. Lck functions in the immune system by initiating the signaling cascade necessary for T-cell activation and development.
Pathways
These proteins impact significant cellular communication networks. p38 is an important player in the MAPK pathway involved in responses to stress stimuli. It interacts with other MAPKs like JNK in controlling cytokine production. Src integrates into the Src-family kinase pathway modulating cell growth and movement by activating downstream proteins such as FAK. VEGF Receptor 2 is pivotal in the VEGF signaling pathway partnering with PI3K and AKT to promote endothelial cell responses. Lck fits into the T-cell receptor pathway where it associates with proteins like ZAP-70 to relay activation signals.
These targets link to several pathological conditions. p38 plays an essential role in inflammatory diseases like arthritis where it mediates inflammatory cytokine production. Src is implicated in cancer carrying mutations or overexpressions in various malignancies often accompanied by proteins such as FAK that drive tumor progression. VEGF Receptor 2 contributes to angiogenesis-related disorders including cancer where its pathway's overactivation supports tumor vasculature development. Lck links with immune disorders like autoimmune diseases as improper signaling here leads to abnormal T-cell responses. In these contexts therapeutic targeting of these proteins can provide compelling strategies to mitigate disease progression.