Abcam, ab282436, Ro 08-2750

Size: 10mg
MW 270.24 Da, Purity 98%. An antagonist of nerve growth factor (NGF) with binding ratio of 1:1, IC 50 = 1 μM. Selectively inhibits binding to p75NTR over TRKA147 at low concentrations. However, it can impair NGF binding to TrkA at higher concentrations (more than 5 mM).
Key facts
CAS number:37854-59-4,
Purity:98%,
Form:SolidSee storage information,
Molecular weight:270.24 Da,
Molecular formula:C13H10N4O3,
PubChem:17756791,
Nature:Synthetic,
Solubility:Soluble in DMSO (up to 2.7 mg/mL),
Biochemical name:7,10-Dimethyl-2,4-dioxo-2,3,4,10-tetrahydrobenzo[g]pteridine-8-carbaldehyde,
Biological description:An antagonist of nerve growth factor (NGF) with binding ratio of 1:1, IC50 = 1 μM. Selectively inhibits binding to p75NTR over TRKA147 at low concentrations. However, it can impair NGF binding to TrkA at higher concentrations (more than 5 mM).,
Canonical smiles:CC1=CC2=C(C=C1C=O)N(C3=NC(=O)NC(=O)C3=N2)C,
InChi:InChI=1S/C13H10N4O3/c1-6-3-8-9(4-7(6)5-18)17(2)11-10(14-8)12(19)16-13(20)15-11/h3-5H,1-2H3,(H,16,19,20),
InChiKey:JDEMVNYMYPJJIM-UHFFFAOYSA-N,
IUPAC Name:7,10-dimethyl-2,4-dioxobenzo[g]pteridine-8-carbaldehyde

Product details:
For obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20°C for several months.

Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C