Abcam, ab282730, Alexa Fluor® 488 Anti-SAA3 antibody [EPR23102-242]

Size: 100µL
Rabbit Recombinant Monoclonal SAA3 antibody - conjugated to Alexa Fluor® 488. Suitable for ICC/IF, Flow Cyt (Intra) and reacts with Mouse samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR23102-242,
Isotype:IgG,
Conjugation:Alexa Fluor® 488,
Excitation/Emission:Ex: 495nm, Em: 519nm,
Carrier free:No,
Reacts with:Mouse,
Applications:ICC/IF, Flow Cyt (Intra)See reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Alexa Fluor® is a registered trademark of Molecular Probes, Inc, a Thermo Fisher Scientific Company. The Alexa Fluor® dye included in this product is provided under an intellectual property license from Life Technologies Corporation. As this product contains the Alexa Fluor® dye, the purchase of this product conveys to the buyer the non-transferable right to use the purchased product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). As this product contains the Alexa Fluor® dye the sale of this product is expressly conditioned on the buyer not using the product or its components, or any materials made using the product or its components, in any activity to generate revenue, which may include, but is not limited to use of the product or its components: in manufacturing; (ii) to provide a service, information, or data in return for payment (iii) for therapeutic, diagnostic or prophylactic purposes; or (iv) for resale, regardless of whether they are sold for use in research. For information on purchasing a license to this product for purposes other than research, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 30% Glycerol (glycerin, glycerine), 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle, Store in the dark

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Serum Amyloid A3 (SAA3) is a member of the serum amyloid A family of proteins and is known for its acute-phase response activity. This protein has an approximate mass of 14 kDa. SAA3 expression is mainly found in extrahepatic tissues in response to pro-inflammatory stimuli. It increases quickly during inflammation and tissue injury serving as a sensitive marker for inflammatory diseases. SAA3's function in the immune response makes it an important protein for researchers studying inflammation and related conditions.
Biological function summary
SAA3 modulates inflammatory responses and may play a role in the pathogenesis of chronic inflammatory diseases. SAA3 proteins can associate with high-density lipoprotein (HDL) in the bloodstream. Such association changes the lipid metabolism and cholesterol transport affecting the body's inflammatory state. The protein also participates in attracting immune cells like leukocytes to the site of inflammation contributing to immune surveillance and tissue repair.
Pathways
Several studies show that SAA3 participates in the toll-like receptor (TLR) signaling and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kB) pathways. These pathways are key regulators of the immune response. SAA3 activation can lead to increased cytokine production such as interleukin-1 (IL-1) and tumor necrosis factor-alpha (TNF-alpha). Its interactions with other SAAs suggest an overlap in their immune-modulating roles making them important players in systemic inflammation.
SAA3 is linked to conditions like chronic inflammatory diseases and cancer. In rheumatoid arthritis for instance elevated levels of SAA3 correlate with disease severity implicating it as a potential biomarker. The protein is also associated with atherosclerosis where it may influence the development of arterial plaques. Its connection to SAA1 and SAA2 which are also related to inflammation and amyloid deposition highlights a broader role for SAAs in inflammatory and amyloid-related pathologies.