Abcam, ab28302, Anti-ADAM23 antibody - Cytoplasmic domain

Size: 100µg
Rabbit Polyclonal ADAM23 antibody. Suitable for WB, ICC/IF and reacts with Rat, Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human ADAM23.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Rat, Human,
Applications:ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human ADAM23. The exact immunogen used to generate this antibody is proprietary information.O75077

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.05% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), 2.9% Sodium chloride, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ADAM23 also known as A Disintegrin And Metalloprotease 23 is a member of the ADAM family of proteases. This protein has a mass of approximately 95 kDa. ADAM23 is expressed in several tissues but it has a significant presence in the brain. The protein mechanically functions by engaging in protease activities though it is uniquely categorized due to its role beyond traditional proteolytic functions. It interacts with surrounding cell-matrix elements through disintegrin domains.
Biological function summary
ADAM23 plays a role in processes such as cell-cell adhesion and signal transduction. It aids in the regulation of synapse formation and maintenance in neuronal cells which is important for proper neural development and function. ADAM23 is not generally considered a part of large protein complexes but collaborates in the cellular environment impacting spatial cellular frameworks and growth signaling cascades.
Pathways
Multiple mechanisms rely on ADAM23 especially those involved in cell signaling. The protein interacts with integrin pathways influencing cellular adhesion and migration dynamics. Furthermore it works closely with other members of the ADAM family such as ADAM22 in modulating signaling pathways critical for neuronal function and transmission.
ADAM23 has shown connections to neurological conditions notably epilepsy and some types of cancer. Disruptions or mutations in the ADAM23 gene have associated alterations in nervous system activity contributing to epilepsy pathogenesis. During cancer progression ADAM23 may interact with tumor-suppressing pathways in which its family member ADAM22 also participates. Understanding ADAM23's role in these diseases can lead to new insights into therapeutic targets.