Abcam, ab284037, Anti-SARS-CoV-2 nsp9 antibody [EPR24855-25]

Size: 20µL / 100µL / 1mL
Rabbit Recombinant Monoclonal R1AB antibody. Suitable for ELISA, WB, Flow Cyt, ICC/IF and reacts with Recombinant full length protein - SARS-CoV-2, Transfected cell line - SARS-CoV-2 samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR24855-25,
Isotype:IgG,
Carrier free:No,
Reacts with:SARS-CoV-2,
Applications:Flow Cyt, WB, ELISA, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.,
Specificity:This antibody detects recombinant and transfected levels of SARS-CoV2 nsp9 only.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SARS-CoV-2 nsp9 also known as non-structural protein 9 plays an important role in viral replication. With a molecular weight of approximately 12 kDa this protein is integral to the replication and transcription complex of SARS-CoV-2 and is expressed during viral infection within host cells. Nsp9 facilitates the synthesis of RNA by binding to single-stranded RNA. This unique RNA-binding feature distinguishes it from other viral proteins implying its specific function in sustaining the viral genome.
Biological function summary
Nsp9 contributes significantly to the process of viral RNA replication. It functions within a complex that includes other non-structural proteins forming a multi-protein assembly necessary for efficient genome replication. This process ensures the viral RNA is correctly copied and translated therefore maintaining the infectivity of SARS-CoV-2. Nsp9's contribution to RNA binding and stabilization plays an important role in controlling the replication accuracy and speed of the virus.
Pathways
Nsp9 participates in the viral replication and transcription pathways of SARS-CoV-2. It interacts closely with proteins like nsp7 and nsp8 which are also a part of the replication machinery. These interactions within the RNA synthesis pathway facilitate the continuous production of viral components sustaining the life cycle of the virus within the host. Understanding these pathways provides insights into potential therapeutic targets to disrupt viral replication.
Nsp9 features prominently in COVID-19 the disease caused by SARS-CoV-2 infection. The protein's role in replication links it to the spread and severity of the infection. Targeting nsp9 could serve as a potential strategy for antiviral therapies. Moreover its interactions with other non-structural proteins such as nsp12 RNA-dependent RNA polymerase highlight the interconnectedness of these proteins in the progression of SARS-CoV-2-related pathology.