Abcam, ab284040, Anti-SARS-CoV-2 orf3d antibody [EPR25045-51]

Size: 20µL / 100µL / 1mL
Rabbit Recombinant Monoclonal ORF3D antibody. Suitable for Flow Cyt (Intra), ICC/IF, I-ELISA, WB and reacts with Transfected cell line - SARS-CoV-2, Synthetic peptide - SARS-CoV-2, Recombinant fragment - SARS-CoV-2 samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR25045-51,
Isotype:IgG,
Carrier free:No,
Reacts with:SARS-CoV-2,
Applications:Flow Cyt (Intra), WB, I-ELISA, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The SARS-CoV-2 orf3d protein also referred to as "Orf3d" in literature serves a unique function in the virus's life cycle. This viral protein has a mass of approximately 12 kDa and is expressed mainly in the cytoplasm of the infected host cells. The Orf3d protein contributes to the virus's ability to manipulate host cellular mechanisms although its detailed mechanical roles are not yet fully understood. Researchers have recently identified it as an open reading frame within the SARS-CoV-2 genome highlighting its importance in viral function.
Biological function summary
The SARS-CoV-2 orf3d protein affects the virus's replication and interaction with host defenses. While not part of any known larger protein complex it has shown effects in viral pathogenicity aiding the virus in evading host immune responses. The protein's activity potentially disrupts normal cellular processes within infected cells assisting the virus in maintaining an environment favorable for its replication.
Pathways
SARS-CoV-2 orf3d plays a part in both the viral replication and immune evasion pathways. It interacts with elements of host cell immune signaling to promote viral survival and replication. The protein is associated with pathways involving the virus's replication machinery potentially interacting with other proteins such as those encoded by SARS-CoV-2 like orf3a which similarly assist in viral infection processes.
SARS-CoV-2 orf3d has implications in COVID-19 pathogenesis. It may contribute to the severity and progression of symptoms observed in infected individuals. Its role in regulating immune response mechanisms shows connections to other viral proteins such as the SARS-CoV-2 nucleocapsid protein which also have implications in viral infection severity. Understanding Orf3d’s interactions could provide insights valuable for therapeutic developments targeting COVID-19.