Abcam, ab284178, Wnt/b-Catenin Pathway Modulator Set

Size: 1Kit
Wnt/b-Catenin Pathway Modulator Set (ab284178) is part of the multiplex kits range. Abcam offers high-quality biological reagents and tools including antibodies, proteins, assays, cell lines and lysates.
Product details:
A convenient set containing 12 ready-to-use Wnt/β-catenin inhibitors and activators. The set comprises high-purity compounds carefully chosen for their selectivity and potency, providing the perfect tool to study Wnt signaling proteins function and β catenin related pathways. All compounds are provided in screw-cap vials, already dissolved in DMSO at a 10 mM concentration. Compounds in DMSO solution may precipitate out of solution when stored at reduced temperatures. Before use, make sure all vials have warmed to room temperature. Please examine all vials to ensure that all material has redissolved – slight warming and/or sonication may be required.
The set contains:
Bafilomycin A1 - Inhibitor of vacuolar H+ -ATPases
BC2059 - beta-catenin antagonist
ICG-001 - Wnt/β-catenin Inhibitor
iCRT5 - A selective CRT inhibitor
IWP-2 - Wnt secretion and processing inhibitor
JW74 - Inhibitor of the Wnt pathway
KY02111 - Wnt signalling inhibitor
Niclosamide - STAT3 and mTORC1 Inhibitor
Nitazoxanide - Nitrothiazole benzamide with anti-parasitic and anti-viral activity
NSC668036 - Wnt signaling Inhibitor
Wnt-C59 - Potent Wnt signaling pathway inhibitor
XAV939 - Tankyrase inhibitor

Properties and Storage Information:
Shipped at conditions-Blue Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information--20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Cathepsin B a well-studied cysteine protease actively participates in protein degradation within lysosomes. With a molecular mass of approximately 25 kDa it is known for its role in numerous cellular processes. Cathepsin B is widely expressed in various tissues including the liver kidney and brain. It often coexists with its protease family members such as cathepsins L and S enhancing its enzymatic activities in different environments. Alternate names like CREBBP particularly in cancer studies emphasize its expanded functional attributes.
Biological function summary
The protein functions by degrading defective or surplus proteins and is pivotal in cellular homeostasis. In lysosomes cathepsin B acts within a larger complex ensuring efficient turnover of cellular components. It also influences apoptosis angiogenesis and immune responses by modulating key proteins and substrates. Cathepsin B interacts with several signaling pathways including TNF-mediated cell death and oxidative stress responses suggesting its regulatory role in cell survival.
Pathways
Cathepsin B forms part of the lysosomal degradation pathway integrating into essential cellular maintenance functions. It aligns closely with the endocytosis pathway influencing the turnover of internalized proteins and receptors. Through these pathways cathepsin B associates with proteins such as STAT3 known for signaling roles in immune responses and cancer development. These interactions highlight the convergence of degradation and signaling pathways in which cathepsin B participates.
Cathepsin B is implicated in tumor progression and Alzheimer's disease. Its overexpression correlates with aggressive cancer phenotypes where it facilitates metastasis through extracellular matrix breakdown. In Alzheimer’s its involvement relates to amyloid precursor protein metabolism and plaque formation. Proteins like PARP1 and PARP14 intersect with cathepsin B in pathways contributing to these diseases illustrating the complex network of interactions driving disease pathology.