Abcam, ab284679, Anti-Synip antibody [EP302Y] - BSA and Azide free

Size: 100µg / 1mg
Rabbit Monoclonal Synip antibody. Carrier free. Suitable for WB, IHC-P and reacts with Human, Mouse, Rat samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EP302Y,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Human, Mouse, Rat,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.,
Specificity:This antibody is specific for Synip. It is predicted to detect the isoform 2 based an sequence analysis.

Product details:
ab284679 is the carrier-free version of
ab40674
This product has switched from a hybridoma to recombinant production method on 13th September 2024.
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Compatibility
This product is compatible with the Maxpar
Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar
is a trademark of Fluidigm Canada Inc.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Synip also known as Syntaxin-binding protein 4 is a protein with a molecular mass of approximately 78 kDa. This protein modulates intracellular trafficking by binding to syntaxin 4 an important component in vesicle transport. Synip is expressed in various tissues with notable expression in adipose tissue muscle and pancreatic beta cells. Its mechanical role involves managing the accessibility of syntaxin 4 impacting the docking and fusion of vesicles with target membranes.
Biological function summary
Synip plays a role in exocytosis a process critical for insulin secretion in pancreatic beta cells. Synip forms a complex with other proteins including SNAP-23 and Munc18c which together regulate vesicle docking and fusion. This function is essential for maintaining glucose homeostasis in the body by ensuring proper release of insulin.
Pathways
Synip interacts with proteins involved in the insulin signaling pathway such as GLUT4 which is responsible for glucose uptake in muscle and adipose tissue. It also plays a role in the SNARE complex formation a critical step in vesicle-mediated transport. Through these interactions Synip contributes to the regulation of glucose metabolism and energy balance in the body.
Synip's function is linked to diabetes mellitus particularly type 2 diabetes due to its role in insulin secretion and glucose homeostasis. Dysregulation or mutations in Synip can impair insulin release leading to insulin resistance. Furthermore Synip has connections with proteins like Syntaxin 4 within the context of metabolic syndrome a condition characterized by increased risk of cardiovascular disease and diabetes due to metabolic imbalances.