Abcam, ab284812, Anti-THOC5 antibody [EP6904] - BSA and Azide free

Size: 100µg / 1mg
Rabbit Monoclonal THOC5 antibody. Carrier free. Suitable for WB, Flow Cyt (Intra) and reacts with Rat, Human samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EP6904,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Rat, Human,
Applications:WB, Flow Cyt (Intra)See reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
ab284812 is the carrier-free version of
ab137051
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Compatibility
This product is compatible with the Maxpar
Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar
is a trademark of Fluidigm Canada Inc.

Properties and Storage Information:
Form-Liquid, Purity-Tissue culture supernatant, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
THOC5 also known as Fms-interacting protein 1 (FIP1L1) or HPR1 is a component of the transcription/export (TREX) complex. With a mass of around 100 kDa THOC5 operates at the intersection of transcription and mRNA processing. This protein localizes mainly in the nucleus where it executes its role in RNA metabolism. THOC5 is necessary for transporting newly synthesized mRNA from the nucleus to the cytoplasm and is constitutively expressed in various tissues including liver and testis.
Biological function summary
This THOC5 protein plays an important role in mRNA processing and export. As part of the TREX complex it assists in coupling transcription with mRNA processing and subsequent export. Through its orchestrated activity THOC5 facilitates the efficient flow of genetic information from DNA to protein synthesis machinery. THOC5 influences the stability and quality of mRNA transcripts by directly binding to certain RNA sequences.
Pathways
One can find THOC5 participating in the mRNA splicing and transport pathways. This protein's role is integrally linked with the DNA-directed RNA polymerase II contributing to the processes that manage RNA synthesis and modification. Additionally THOC5 interacts with other components of the TREX complex such as THOC2 and THOC7 to maintain proper RNA metabolism and cellular function.
THOC5 has relevance to cancer. Some studies have found dysregulation of THOC5 in various malignancies including leukemia and liver cancer. Its association with the FUS protein suggests a link to neurodegenerative conditions since FUS mutations show involvement in amyotrophic lateral sclerosis (ALS). Imbalances in THOC5 levels can cause aberrant mRNA processing contributing to disease progression.