Abcam, ab28692, Anti-GHRHR antibody

Size: 100µL
Rabbit Polyclonal GHRHR antibody. Suitable for IHC-P and reacts with Human samples. Cited in 28 publications. Immunogen corresponding to Synthetic Peptide within Human Growth hormone-releasing hormone receptor aa 400 to C-terminus conjugated to Keyhole Limpet Haemocyanin.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human Growth hormone-releasing hormone receptor aa 400 to C-terminus conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.Q02643

Properties and Storage Information:
Form-Liquid, Purity-Whole antiserum, Storage buffer-Preservative: 0.05% Sodium azideConstituents: Whole serum, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
GHRHR also known as the growth hormone-releasing hormone receptor is an important protein that plays an important role mechanistically in the human body. This receptor is located on the cell membrane and binds to growth hormone-releasing hormone (GHRH). GHRHR is expressed predominantly in the pituitary gland. It has a molecular mass of approximately 44 kDa and its activation leads to the intracellular signaling cascades that promote growth hormone secretion.
Biological function summary
The interaction of GHRHR with GHRH is necessary for the regulation of growth hormone release. This receptor is not part of a larger complex; instead it functions individually as a receptor. GHRHR's role in stimulating growth hormone release makes it essential for normal growth metabolism and body composition. It influences processes like protein synthesis lipolysis and the maintenance of normal glucose levels.
Pathways
GHRHR operates within the growth hormone signaling pathway. This pathway involves the activation of GHRHR by GHRH which leads to the stimulation of adenylate cyclase increasing cyclic AMP levels resulting in growth hormone release. This pathway is interconnected with other signaling proteins like somatostatin which acts as an inhibitor of growth hormone secretion providing a balance in growth regulation.
GHRHR has been linked to conditions affecting growth such as dwarfism and gigantism. Mutations in the GHRHR gene can disrupt normal growth hormone signaling leading to reduced or excessive growth. Gigantism involves increased growth hormone secretion often related to pituitary gland abnormalities. In contrast dwarfism may result from insufficient growth hormone action due to receptor defects. GHRHR's interaction with GHRH and its role in growth hormone regulation highlight its significance in these growth-related disorders.