Abcam, ab286998, KR-33493

Size: 5mg / 25mg
MW 460.3 Da, Purity >98%. 4-[[2-[(4-bromophenyl)thio]acetyl]amino]-1-(2-phenylethyl)-1H-pyrazole-3-carboxylic acid.
Key facts
CAS number:1021497-97-1,
Purity:>98%,
Form:SolidSee storage information,
Molecular weight:460.3 Da,
Molecular formula:C20H18BrN3O3S,
PubChem:25009726,
Nature:Synthetic,
Solubility:Soluble in DMSO,
Biochemical name:Unii-nch0QD81ZR,
Biological description:4-[[2-[(4-bromophenyl)thio]acetyl]amino]-1-(2-phenylethyl)-1H-pyrazole-3-carboxylic acid,
Canonical smiles:C1=CC=C(C=C1)CCN2C=C(C(=N2)C(=O)O)NC(=O)CSC3=CC=C(C=C3)Br,
InChi:InChI=1S/C20H18BrN3O3S/c21-15-6-8-16(9-7-15)28-13-18(25)22-17-12-24(23-19(17)20(26)27)11-10-14-4-2-1-3-5-14/h1-9,12H,10-11,13H2,(H,22,25)(H,26,27),
InChiKey:ZRLJEHIUGYTTSZ-UHFFFAOYSA-N,
IUPAC Name:4-[[2-(4-bromophenyl)sulfanylacetyl]amino]-1-(2-phenylethyl)pyrazole-3-carboxylic acid

Product details:
This product is manufactured by BioVision, an Abcam company and was previously called B2300 KR-33493. B2300-25 is the same size as the 25 mg size of ab286998.

Properties and Storage Information:
Shipped at conditions-Blue Ice, Appropriate long-term storage conditions--20°C, Storage information-Store in the dark, This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
FAF1 also known as FAS-associated factor 1 functions mechanically by interacting with the FAS receptor to modulate apoptotic processes. It has a molecular weight of approximately 74 kDa. This protein can be found in various tissues with higher expression in the brain liver and kidney. The expression suggests its diverse roles in cellular processes across different organ systems.
Biological function summary
FAF1 interacts with ubiquitin-like modifiers to influence the cellular response to stress. It is part of the death-inducing signaling complex (DISC) where it contributes to the regulation of apoptosis. In addition to apoptosis FAF1 plays a role in regulating protein degradation processes connecting its function to proteostasis in cells.
Pathways
FAF1 takes part in significant cellular processes including the apoptotic signaling pathway and the NF-kB signaling pathway. In these pathways it interacts with FAS and NF-kB proteins contributing to cell death and inflammatory responses respectively. The influence on these pathways showcases its role in maintaining balance between cell survival and cell death.
FAF1 displays connections to neurodegenerative diseases and cancers. It has been implicated in the pathogenesis of Parkinson's disease where its dysregulation can affect neuronal survival. Furthermore its interaction with FAS in the apoptosis pathway links FAF1 to certain types of cancers where apoptotic failure results in uncontrolled cell growth. Understanding FAF1's role is essential for developing therapeutic strategies targeting these pathways and associated conditions.