Abcam, ab287028, IITZ-01

Size: 1mg
MW 482.5 Da, Purity >98%. IITZ-01 (ab287028) is a potent lysosomotropic autophagy inhibitor; displays >10-fold potent autophagy inhibition than Chloroquine; enhances autophagosome accumulation but inhibits autophagosomal degradation by impairing lysosomal function, finally resulting in the inhibition of autophagy. Displays potent anticancer activity.
Key facts
CAS number:1807988-47-1,
Purity:>98%,
Form:SolidSee storage information,
Molecular weight:482.5 Da,
Molecular formula:C26H23FN8O,
PubChem:134817273,
Nature:Synthetic,
Solubility:Soluble in DMSO to >100 mM,
Biochemical name:CID 134817273,
Biological description:IITZ-01 (ab287028) is a potent lysosomotropic autophagy inhibitor; displays >10-fold potent autophagy inhibition than Chloroquine; enhances autophagosome accumulation but inhibits autophagosomal degradation by impairing lysosomal function, finally resulting in the inhibition of autophagy. Displays potent anticancer activity.,
Canonical smiles:C1COCCN1C2=NC(=NC(=N2)NC3=CC=C(C=C3)F)NC4=CC=C(C=C4)C5=NC6=CC=CC=C6N5,
InChi:InChI=1S/C26H23FN8O/c27-18-7-11-20(12-8-18)29-25-32-24(33-26(34-25)35-13-15-36-16-14-35)28-19-9-5-17(6-10-19)23-30-21-3-1-2-4-22(21)31-23/h1-12H,13-16H2,(H,30,31)(H2,28,29,32,33,34),
InChiKey:XGEDDGLPNSLBFE-UHFFFAOYSA-N,
IUPAC Name:4-N-[4-(1H-benzimidazol-2-yl)phenyl]-2-N-(4-fluorophenyl)-6-morpholin-4-yl-1,3,5-triazine-2,4-diamine

Product details:
This product is manufactured by BioVision, an Abcam company and was previously called B2378 IITZ-01. B2378-5 is the same size as the 5 mg size of ab287028.

Properties and Storage Information:
Shipped at conditions-Blue Ice, Appropriate long-term storage conditions--20°C