Abcam, ab287065, CHZ868

Size: 5mg / 25mg
MW 423.4 Da, Purity >98%. CHZ868 is a potent and selective type II JAK2 inhibitor (IC₅₀ = 110 nM). JAK2 and MPL mutant cell lines are sensitive to CHZ868, including type I JAK inhibitor persistent cells. CHZ868 displays significant activity in murine MPN models and induces reductions in mutant allele burden not observed with type I JAK inhibitors.
Key facts
CAS number:1895895-38-1,
Purity:>98%,
Form:SolidSee storage information,
Molecular weight:423.4 Da,
Molecular formula:C22H19F2N5O2,
PubChem:91885989,
Nature:Synthetic,
Solubility:>100 mg/ml DMSO,
Biochemical name:Chz868,
Biological description:CHZ868 is a potent and selective type II JAK2 inhibitor (IC₅₀ = 110 nM). JAK2 and MPL mutant cell lines are sensitive to CHZ868, including type I JAK inhibitor persistent cells. CHZ868 displays significant activity in murine MPN models and induces reductions in mutant allele burden not observed with type I JAK inhibitors.,
Canonical smiles:CC1=C(C=CC2=C1N=C(N2C)NC3=C(C=C(C=C3)F)F)OC4=CC(=NC=C4)NC(=O)C,
InChi:InChI=1S/C22H19F2N5O2/c1-12-19(31-15-8-9-25-20(11-15)26-13(2)30)7-6-18-21(12)28-22(29(18)3)27-17-5-4-14(23)10-16(17)24/h4-11H,1-3H3,(H,27,28)(H,25,26,30),
InChiKey:KQQLBXFPTDVFAJ-UHFFFAOYSA-N,
IUPAC Name:N-[4-[2-(2,4-difluoroanilino)-1,4-dimethylbenzimidazol-5-yl]oxypyridin-2-yl]acetamide

Product details:
This product is manufactured by BioVision, an Abcam company and was previously called B2475 CHZ868. B2475-5 is the same size as the 5 mg size of ab287065.

Properties and Storage Information:
Shipped at conditions-Blue Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-Store in the dark, This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Interferon beta 1 (Ifnb1) also known as IFN-β is an important protein in the immune system. It has a mass of around 20 kDa and is primarily expressed in fibroblasts and monocytes. This protein functions as a type I interferon involved in the regulation of immune responses against pathogens especially viruses. Ifnb1 acts to limit viral replication by inducing the expression of antiviral proteins within infected and neighboring cells.
Biological function summary
Ifnb1 is an important player in the immune defense system. It is involved in enhancing the activity of immune cells such as natural killer cells and macrophages. The protein is not part of a complex but interacts with receptors on the cell surface to trigger signaling pathways. Its antiviral activities include the inhibition of viral protein synthesis and enhancement of antigen presentation to T cells making it important for innate and adaptive immunity.
Pathways
Ifnb1 is integral in the JAK-STAT signaling pathway which is important for relaying information from specific cytokines to the cell nucleus. This pathway includes proteins like JAK1 and STAT1 which interact with Ifnb1 to modulate the transcription of genes involved in immune responses. Additionally Ifnb1 is involved in the interferon regulatory pathways working with other type I interferons to control viral infections and modulate the immune response.
Ifnb1 is linked to multiple sclerosis and hepatitis C. In multiple sclerosis Ifnb1 modulates the immune response to reduce inflammation and prevent the progression of the disease. Its connection to hepatitis C involves decreasing viral replication and improving liver health. Proteins such as Hepatitis C virus NS5A and immune system component major histocompatibility complex (MHC) are associated with Ifnb1's actions in these disorders.